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    Mb myoglobin [ Mus musculus (house mouse) ]

    Gene ID: 17189, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mbprovided by MGI
    Official Full Name
    myoglobinprovided by MGI
    Primary source
    MGI:MGI:96922
    See related
    Ensembl:ENSMUSG00000018893 AllianceGenome:MGI:96922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including nitrite reductase activity; oxygen binding activity; and oxygen carrier activity. Acts upstream of or within several processes, including brown fat cell differentiation; enucleate erythrocyte differentiation; and response to hypoxia. Predicted to be located in sarcoplasm. Is expressed in brown fat; heart; skeletal muscle; and somite. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human MB (myoglobin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward heart adult (RPKM 4675.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D3; 15 36.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76899687..76934868, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77015487..77050668, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53916 Neighboring gene predicted gene, 52199 Neighboring gene VISTA enhancer mm106 Neighboring gene STARR-seq mESC enhancer starr_39074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:76901831-76902180 Neighboring gene apolipoprotein L 6 Neighboring gene predicted gene, 24753 Neighboring gene predicted gene, 53899 Neighboring gene RNA binding protein, fox-1 homolog (C. elegans) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acute inhibition of myoglobin impairs contractility and energy state of iNOS-overexpressing hearts. Wunderlich C, et al. Circ Res, 2003 Jun 27. PMID 12775582
    2. The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Ormerod JO, et al. Cardiovasc Res, 2011 Feb 15. PMID 20889759, Free PMC Article
    3. Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy. Molojavyi A, et al. Physiol Genomics, 2010 Apr 1. PMID 20145201
    4. Myoglobin over-expression attenuates angiogenic response in hindlimb ischemia in mice. Yang YG, et al. Chin Med J (Engl), 2009 May 5. PMID 19493440
    5. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Hendgen-Cotta UB, et al. Proc Natl Acad Sci U S A, 2008 Jul 22. PMID 18632562, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis.
      Title: Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis.
    2. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
      Title: Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.
    3. Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets.
      Title: Myoglobin, expressed in brown adipose tissue of mice, regulates the content and activity of mitochondria and lipid droplets.
    4. The authors here unravel a novel role of cardiac myoglobin in governing fatty acid metabolism to ensure the physiological energy production through beta-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions.
      Title: A novel physiological role for cardiac myoglobin in lipid metabolism.
    5. Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
      Title: IGF-1 Attenuates Hypoxia-Induced Atrophy but Inhibits Myoglobin Expression in C2C12 Skeletal Muscle Myotubes.
    6. the novel cancer-associated MB splice variants exhibited increased expression in tumor cells subjected to experimental hypoxia; the novel gene regulatory mechanisms unveiled in this study support the idea of a non-canonical role of MB during carcinogenesis
      Title: Extensive transcriptional complexity during hypoxia-regulated expression of the myoglobin gene in cancer.
    7. Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis
      Title: Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis.
    8. Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
      Title: Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
    9. Show a high capacity of myoglobin-deficient mice to adapt to catecholamine induced cardiac stress which is associated with activation of a distinct cardiac gene expression program.
      Title: Myoglobin-deficient mice activate a distinct cardiac gene expression program in response to isoproterenol-induced hypertrophy.
    10. Endogenous nitrite reduction to NO. via the heme globin myoglobin enhances blood flow and matches O(2) supply to increased metabolic demands under hypoxic conditions.
      Title: Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitrite reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxygen carrier activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxygen carrier activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within enucleate erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in removal of superoxide radicals ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in sarcoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myoglobin
    Names
    nitrite reductase MB
    pseudoperoxidase MB
    NP_001157519.1
    NP_001157520.1
    NP_038621.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164047.1 → NP_001157519.1  myoglobin

      See identical proteins and their annotated locations for NP_001157519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC157554, AK137456, BX527493
      Consensus CDS
      CCDS27597.1
      UniProtKB/Swiss-Prot
      P04247
      UniProtKB/TrEMBL
      Q3UVB1
      Related
      ENSMUSP00000125995.2, ENSMUST00000169226.9
      Conserved Domains (1) summary
      cl21461
      Location:6 → 154
      Globin-like; Globin-like protein superfamily

    2. NM_001164048.1 → NP_001157520.1  myoglobin

      See identical proteins and their annotated locations for NP_001157520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AA271284, AK137456, BX527493
      Consensus CDS
      CCDS27597.1
      UniProtKB/Swiss-Prot
      P04247
      UniProtKB/TrEMBL
      Q3UVB1
      Related
      ENSMUSP00000019037.9, ENSMUST00000019037.10
      Conserved Domains (1) summary
      cl21461
      Location:6 → 154
      Globin-like; Globin-like protein superfamily

    3. NM_013593.3 → NP_038621.2  myoglobin

      See identical proteins and their annotated locations for NP_038621.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
      Source sequence(s)
      AC157554, AL603843, BX527493
      Consensus CDS
      CCDS27597.1
      UniProtKB/Swiss-Prot
      P04247
      UniProtKB/TrEMBL
      Q3UVB1
      Related
      ENSMUSP00000128399.2, ENSMUST00000166179.9
      Conserved Domains (1) summary
      cl21461
      Location:6 → 154
      Globin-like; Globin-like protein superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76899687..76934868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04247.3 GenPept UniProtKB/Swiss-Prot:P04247

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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