Mgam maltase-glucoamylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mgamprovided by MGI
Official Full Name: maltase-glucoamylaseprovided by MGI
Primary source: MGI:MGI:1203495
See related: Ensembl:ENSMUSG00000068587 AllianceGenome:MGI:1203495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MGA; 6030407P20Rik
Summary: Enables alpha-1,4-glucosidase activity and amylase activity. Predicted to be involved in dextrin catabolic process and maltose catabolic process. Predicted to be located in apical plasma membrane. Is expressed in alimentary system; intestine; liver; midgut; and rectum. Orthologous to human MGAM (maltase-glucoamylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 113.2), small intestine adult (RPKM 89.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 18.82 cM

Exon count:: 96

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (40605765..40746057)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (40628831..40769123)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

investigation of dietary control of Mgam expression in jejunum: high starch diet induces Mgam through mechanism involving increased acetylation of histones and increased binding of CREBBP, CDX2, and HNF1 to Mgam gene
Title: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/low-fat diet in mice.
mucosal alpha-glucogenic activity of Mgam plays a crucial role in the regulation of prandial glucose homeostasis
Title: Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice.
The alpha-glucogenic activities of the jejunal mucosa with and without added recombinant pancreatic alpha-amylase, using a range of food starch substrates are reported.
Title: Contribution of mucosal maltase-glucoamylase activities to mouse small intestinal starch alpha-glucogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

D6Mit382 (e-PCR), detects polymorphism
- UniSTS:142594

Mgam (e-PCR), detects polymorphism
- UniSTS:546861

RH126673 (e-PCR)
- UniSTS:207939

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,4-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-1,4-glucosidase activity	ISO Inferred from Sequence Orthology more info
enables amylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in dextrin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in maltose catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: maltase-glucoamylase

NP_001164474.1

EC 3.2.1.20

EC 3.2.1.3

NP_001355804.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506105.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506107.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506108.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506109.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506110.1

EC 3.2.1.20

EC 3.2.1.3

XP_006506111.1

EC 3.2.1.20

EC 3.2.1.3

XP_011239632.1

EC 3.2.1.20

EC 3.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171003.1 → NP_001164474.1 maltase-glucoamylase isoform 2

See identical proteins and their annotated locations for NP_001164474.1

Status: VALIDATED

Source sequence(s)

AC153378, AC158685

Consensus CDS

CCDS51755.1

UniProtKB/TrEMBL

B5THE2

Related

ENSMUSP00000071466.7, ENSMUST00000071535.10

Conserved Domains (5) summary

smart00018
Location:65 → 110

PD; P or trefoil or TFF domain

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam01055
Location:323 → 794

Glyco_hydro_31; Glycosyl hydrolases family 31

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
NM_001368875.1 → NP_001355804.1 maltase-glucoamylase isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC153378, AC158685

Consensus CDS

CCDS90041.1

UniProtKB/TrEMBL

A0A571BF69

Conserved Domains (7) summary

smart00018
Location:2720 → 2764

PD; P or trefoil or TFF domain

cd00111
Location:1828 → 1867

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:65 → 107

Trefoil; Trefoil (P-type) domain

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1189 → 1690

Glyco_hydro_31; Glycosyl hydrolases family 31

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

40605765..40746057

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506044.2 → XP_006506107.1 maltase-glucoamylase isoform X1

See identical proteins and their annotated locations for XP_006506107.1

UniProtKB/TrEMBL

A0A571BF69

Conserved Domains (7) summary

smart00018
Location:2720 → 2764

PD; P or trefoil or TFF domain

cd00111
Location:1828 → 1867

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:65 → 107

Trefoil; Trefoil (P-type) domain

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1189 → 1690

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_006506042.1 → XP_006506105.1 maltase-glucoamylase isoform X1

See identical proteins and their annotated locations for XP_006506105.1

UniProtKB/TrEMBL

A0A571BF69

Related

ENSMUSP00000158794.2, ENSMUST00000238599.2

Conserved Domains (7) summary

smart00018
Location:2720 → 2764

PD; P or trefoil or TFF domain

cd00111
Location:1828 → 1867

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:65 → 107

Trefoil; Trefoil (P-type) domain

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1189 → 1690

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_006506048.1 → XP_006506111.1 maltase-glucoamylase isoform X5

Conserved Domains (7) summary

smart00018
Location:934 → 972

PD; P or trefoil or TFF domain

cd00111
Location:1828 → 1867

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:65 → 107

Trefoil; Trefoil (P-type) domain

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1189 → 1690

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_011241330.1 → XP_011239632.1 maltase-glucoamylase isoform X6

Conserved Domains (6) summary

smart00018
Location:1825 → 1869

PD; P or trefoil or TFF domain

cd06602
Location:342 → 705

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1087 → 1208

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:65 → 107

Trefoil; Trefoil (P-type) domain

pfam16863
Location:124 → 233

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:2083 → 2585

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_006506045.3 → XP_006506108.1 maltase-glucoamylase isoform X2

Conserved Domains (7) summary

smart00018
Location:2697 → 2741

PD; P or trefoil or TFF domain

cd00111
Location:1805 → 1844

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:319 → 682

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1064 → 1185

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:42 → 84

Trefoil; Trefoil (P-type) domain

pfam16863
Location:101 → 210

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1166 → 1667

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_006506046.4 → XP_006506109.1 maltase-glucoamylase isoform X3

Conserved Domains (7) summary

smart00018
Location:2690 → 2734

PD; P or trefoil or TFF domain

cd00111
Location:1798 → 1837

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:312 → 675

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:1057 → 1178

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam00088
Location:35 → 77

Trefoil; Trefoil (P-type) domain

pfam16863
Location:94 → 203

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1159 → 1660

Glyco_hydro_31; Glycosyl hydrolases family 31
XM_006506047.1 → XP_006506110.1 maltase-glucoamylase isoform X4

Conserved Domains (6) summary

smart00018
Location:2607 → 2651

PD; P or trefoil or TFF domain

cd00111
Location:1715 → 1754

Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

cd06602
Location:229 → 592

GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase

cd14752
Location:974 → 1095

GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)

pfam16863
Location:11 → 120

NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

pfam01055
Location:1076 → 1577

Glyco_hydro_31; Glycosyl hydrolases family 31