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    Pabpn1l poly(A)binding protein nuclear 1-like [ Mus musculus (house mouse) ]

    Gene ID: 382035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pabpn1lprovided by MGI
    Official Full Name
    poly(A)binding protein nuclear 1-likeprovided by MGI
    Primary source
    MGI:MGI:2685954
    See related
    Ensembl:ENSMUSG00000069867 AllianceGenome:MGI:2685954
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1108; ePABP2; Pabpnl1
    Summary
    Enables poly(A) binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of macromolecule metabolic process. Located in cytoplasm. Is expressed in 1-cell stage embryo; gonad; retina; and thymus. Orthologous to human PABPN1L (PABPN1 like, cytoplasmic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 1.6), thymus adult (RPKM 0.1) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pabpn1l in Genome Data Viewer
    Location:
    8 E1; 8 71.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123346210..123349474, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122619471..122622735, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1777 Neighboring gene trafficking protein particle complex 2L Neighboring gene microRNA 6396 Neighboring gene CBFA2/RUNX1 translocation partner 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125190682-125190990 Neighboring gene STARR-positive B cell enhancer ABC_E9748 Neighboring gene STARR-positive B cell enhancer ABC_E5048 Neighboring gene predicted gene 10612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125233759-125233868 Neighboring gene predicted gene, 53467 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125235898-125236081 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125236552-125237022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PABPN1L is required for maternal mRNA degradation after meiosis resumption. Emori C, et al. J Reprod Dev, 2024 Feb 19. PMID 38057116, Free PMC Article
    2. PABPN1L assemble into "ring-like" aggregates in the cytoplasm of MII oocytes and is associated with female infertility†. Wang Y, et al. Biol Reprod, 2022 Jan 13. PMID 34726234
    3. PABPN1 functions as a hub in the assembly of nuclear poly(A) domains that are essential for mouse oocyte development. Dai XX, et al. Sci Adv, 2022 Oct 28. PMID 36306357, Free PMC Article
    4. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Seli E, et al. Proc Natl Acad Sci U S A, 2005 Jan 11. PMID 15630085, Free PMC Article
    5. Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development. Good PJ, et al. Genesis, 2004 Apr. PMID 15083517

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PABPN1L is required for maternal mRNA degradation after meiosis resumption.
      Title: PABPN1L is required for maternal mRNA degradation after meiosis resumption.
    2. PABPN1L assemble into ""ring-like"" aggregates in the cytoplasm of MII oocytes and is associated with female infertilitydagger.
      Title: PABPN1L assemble into "ring-like" aggregates in the cytoplasm of MII oocytes and is associated with female infertility†.
    3. PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.
      Title: PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal-to-zygotic transition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables poly(A) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maternal-to-zygotic transition of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    embryonic polyadenylate-binding protein 2
    Names
    T-cell receptor alpha chain V region (8/10-2)
    ePABP-2
    embryonic poly(A) binding protein 2
    embryonic poly(A)-binding protein type II
    poly(A)-binding protein nuclear-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007462.1 → NP_001007463.1  embryonic polyadenylate-binding protein 2

      See identical proteins and their annotated locations for NP_001007463.1

      Status: PROVISIONAL

      Source sequence(s)
      BK001615
      Consensus CDS
      CCDS22743.1
      UniProtKB/Swiss-Prot
      B9EJ43, Q5XFR0
      UniProtKB/TrEMBL
      B7ZP52
      Related
      ENSMUSP00000090747.3, ENSMUST00000093059.3
      Conserved Domains (2) summary
      COG0724
      Location:134 → 227
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:144 → 220
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123346210..123349474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XFR0.1 GenPept UniProtKB/Swiss-Prot:Q5XFR0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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