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    PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Bos taurus (domestic cattle) ]

    Gene ID: 282306, updated on 29-Jan-2025

    Summary

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    Official Symbol
    PIK3CAprovided by VGNC
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:32889
    See related
    Ensembl:ENSBTAG00000009232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3CA in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (87871397..87964022, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 639 Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene small nucleolar RNA SNORA20 Neighboring gene uncharacterized LOC132345663 Neighboring gene zinc finger matrin-type 3 Neighboring gene uncharacterized LOC112447549 Neighboring gene transfer RNA glycine (anticodon UCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Azadi S, et al. Adv Exp Med Biol, 2016. PMID 26427433
    2. Critical evaluation of the two-state model describing the equilibrium unfolding of the PI3K SH3 domain by time-resolved fluorescence resonance energy transfer. Kishore M, et al. Biochemistry, 2013 Dec 31. PMID 24325755
    3. Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Meunier FA, et al. Mol Biol Cell, 2005 Oct. PMID 16055506, Free PMC Article
    4. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Miled N, et al. Science, 2007 Jul 13. PMID 17626883
    5. Role of the PI3K regulatory subunit in the control of actin organization and cell migration. Jiménez C, et al. J Cell Biol, 2000 Oct 16. PMID 11038173, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that both class I and III phosphoinositide 3-kinases (PI3Ks) re present in trafficking vesicles.
      Title: Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.
    2. There are multiple conformations in equilibrium during the course of PI3K SH3 domain unfolding.
      Title: Critical evaluation of the two-state model describing the equilibrium unfolding of the PI3K SH3 domain by time-resolved fluorescence resonance energy transfer.
    3. Production of PtdIns3P by PI3K-C2alpha is required for acquisition of fusion competence in neurosecretion.
      Title: Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.
    4. crystallographic and biochemical approaches used to gain insight into activating mutations in two noncatalytic p110alpha domains-the adaptor-binding and the helical domains
      Title: Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IB IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    PI3-kinase p110 subunit alpha
    PI3-kinase subunit alpha
    PI3K
    PI3K-alpha
    PI3Kalpha
    p110alpha
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphoinositide-3-kinase, catalytic, alpha polypeptide
    ptdIns-3-kinase p110
    ptdIns-3-kinase subunit alpha
    ptdIns-3-kinase subunit p110-alpha
    serine/threonine protein kinase PIK3CA
    NP_776999.1
    XP_024848781.1
    XP_024848812.1
    XP_059743896.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174574.1 → NP_776999.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_776999.1

      Status: PROVISIONAL

      Source sequence(s)
      M93252
      UniProtKB/Swiss-Prot
      P32871
      UniProtKB/TrEMBL
      A0AAF6YT82
      Related
      ENSBTAP00070005919.1, ENSBTAT00070010294.1
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      87871397..87964022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993013.2 → XP_024848781.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P32871
      UniProtKB/TrEMBL
      A0AAF6YT82
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    2. XM_024993044.2 → XP_024848812.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P32871
      UniProtKB/TrEMBL
      A0AAF6YT82
      Conserved Domains (5) summary
      cd08398
      Location:325 → 484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      smart00144
      Location:173 → 292
      PI3K_rbd; PI3-kinase family, Ras-binding domain
      cd00872
      Location:525 → 696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:695 → 1064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    3. XM_059887913.1 → XP_059743896.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1

      UniProtKB/Swiss-Prot
      P32871
      UniProtKB/TrEMBL
      A0AAF6YT82
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32871.1 GenPept UniProtKB/Swiss-Prot:P32871

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