BBS1 Bardet-Biedl syndrome 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BBS1provided by FlyBase
Official Full Name: Bardet-Biedl syndrome 1provided by FlyBase
Primary source: FLYBASE:FBgn0035741
Locus tag: Dmel_CG14825
See related: AllianceGenome:FB:FBgn0035741
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14825; Dmel\CG14825
Summary: Predicted to enable patched binding activity and smoothened binding activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of BBSome. Predicted to be active in axoneme and centrosome. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome and Bardet-Biedl syndrome 1. Orthologous to human BBS1 (Bardet-Biedl syndrome 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7125905..7128118)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7119005..7121218)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables smoothened binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	IEA Inferred from Electronic Annotation more info
part_of BBSome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IC Inferred by Curator more info	PubMed