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    spartin spartin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spartinprovided by FlyBase
    Official Full Name
    spartinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037265
    Locus tag
    Dmel_CG12001
    See related
    AllianceGenome:FB:FBgn0037265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12001; Dmel\CG12001; dSp; Spartin
    Summary
    Enables small GTPase binding activity. Involved in negative regulation of BMP signaling pathway; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of receptor internalization. Located in early endosome; presynaptic membrane; and terminal bouton. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval neuromuscular junction; ganglia; and larval muscle system. Used to study Troyer syndrome. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spartin in Genome Data Viewer
    Location:
    82C5-82D1; 3-47.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4654800..4657985)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (480522..483707)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44155 Neighboring gene Karyopherin beta 3 Neighboring gene ripped pocket Neighboring gene long non-coding RNA:CR44156 Neighboring gene smallish Neighboring gene long non-coding RNA:CR44157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Ring J, et al. Microb Cell, 2017 Nov 30. PMID 29234670, Free PMC Article
    2. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
    3. Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Nahm M, et al. Neuron, 2013 Feb 20. PMID 23439121, Free PMC Article
    4. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article
    5. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Tsubouchi A, et al. Curr Biol, 2012 Nov 20. PMID 23103192, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor internalization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spartin
    Names
    CG12001-PA
    CG12001-PB
    spartin-PA
    spartin-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4654800..4657985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141228.2 → NP_649485.1  spartin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86MQ7, Q9VN45
      UniProtKB/TrEMBL
      A0A0B4K6I5
      Related
      FBpp0078501
      Conserved Domains (2) summary
      cd02679
      Location:15 → 97
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:325 → 511
      Senescence; Senescence-associated protein

    2. NM_001259981.1 → NP_001246910.1  spartin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86MQ7, Q9VN45
      UniProtKB/TrEMBL
      A0A0B4K6I5
      Conserved Domains (2) summary
      cd02679
      Location:15 → 97
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam06911
      Location:325 → 511
      Senescence; Senescence-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6I5 A0A0B4K6I5
    Q9VN45.1 Q9VN45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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