PolE4 DNA polymerase epsilon subunit 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PolE4provided by FlyBase
Official Full Name: DNA polymerase epsilon subunit 4provided by FlyBase
Primary source: FLYBASE:FBgn0034726
Locus tag: Dmel_CG11301
See related: AllianceGenome:FB:FBgn0034726
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11301; BcDNA:GM21739; CG11301; Dmel\CG11301; Mes4; MES4; NF-Yc
Summary: Predicted to enable protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval fat body; endoderm anlage; ganglia; and imaginal disc. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22411789..22412582)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18299294..18300087)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

Names: CG11301-PA; CG11301-PB; Mes4; Mesoderm-expressed 4; NF-YC-like; PolE4-PA; PolE4-PB

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