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    Npc2g Niemann-Pick type C-2g [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43648, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Npc2gprovided by FlyBase
    Official Full Name
    Niemann-Pick type C-2gprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039800
    Locus tag
    Dmel_CG11314
    See related
    AllianceGenome:FB:FBgn0039800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE56164; CG11314; Dmel\CG11314; npc2g
    Summary
    Predicted to enable sterol binding activity. Involved in mesoderm development. Located in extracellular region. Is expressed in adult head; adult heart; head mesoderm; plasmatocyte primordium; and somatic trunk mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Npc2g in Genome Data Viewer
    Location:
    100A3-100A3; 3-101 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30744605..30745263, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26570327..26570985, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43238 Neighboring gene Niemann-Pick type C-2h

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Hang S, et al. Cell Host Microbe, 2014 Nov 12. PMID 25525791, Free PMC Article
    2. The Effect of Common Inversion Polymorphisms In(2L)t and In(3R)Mo on Patterns of Transcriptional Variation in Drosophila melanogaster. Lavington E, et al. G3 (Bethesda), 2017 Nov 6. PMID 28916647, Free PMC Article
    3. Drosophila melanogaster NPC2 proteins bind bacterial cell wall components and may function in immune signal pathways. Shi XZ, et al. Insect Biochem Mol Biol, 2012 Aug. PMID 22580186, Free PMC Article
    4. Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease. Huang X, et al. Development, 2007 Oct. PMID 17804599
    5. TRAP-seq Profiling and RNAi-Based Genetic Screens Identify Conserved Glial Genes Required for Adult Drosophila Behavior. Ng FS, et al. Front Mol Neurosci, 2016. PMID 28066175, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular cholesterol transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    Niemann-Pick type C-2g
    Names
    CG11314-PA
    CG11314-PB
    Npc2g-PA
    Npc2g-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30744605..30745263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143566.2 → NP_651823.1  Niemann-Pick type C-2g, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGP0, Q9VA42
      Related
      FBpp0085085
      Conserved Domains (1) summary
      cd00916
      Location:28 → 155
      Npc2_like; Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived ...

    2. NM_001260446.2 → NP_001247375.1  Niemann-Pick type C-2g, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGP0, Q9VA42
      Conserved Domains (1) summary
      cd00916
      Location:28 → 155
      Npc2_like; Niemann-Pick type C2 (Npc2) is a lysosomal protein in which a mutation in the gene causes a rare form of Niemann-Pick type C disease, an autosomal recessive lipid storage disorder characterized by accumulation of low-density lipoprotein-derived ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGP0 Q8IGP0
    Q9VA42 Q9VA42

    Gene LinkOut

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