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    mora morgana [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    moraprovided by FlyBase
    Official Full Name
    morganaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029503
    Locus tag
    Dmel_CG6198
    See related
    AllianceGenome:FB:FBgn0029503
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6198; Chord; CHORD; chp; dCHORDC1; Dmel\CG6198; Q9U4A3
    Summary
    Predicted to enable zinc ion binding activity. Involved in several processes, including centrosome duplication; regulation of dendrite development; and regulation of microtubule cytoskeleton organization. Located in mitotic spindle microtubule; nucleus; and perinuclear region of cytoplasm. Is expressed in organism. Orthologous to several human genes including CHORDC1 (cysteine and histidine rich domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mora in Genome Data Viewer
    Location:
    95E8-95E8; 3-83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24186359..24187785)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20012081..20013507)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Shimono K, et al. Sci Rep, 2014 Mar 19. PMID 24643112, Free PMC Article
    2. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. Shirasu K, et al. Cell, 1999 Nov 12. PMID 10571178
    3. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. Ferretti R, et al. Dev Cell, 2010 Mar 16. PMID 20230755
    4. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. Garcia-Ranea JA, et al. FEBS Lett, 2002 Oct 9. PMID 12372593
    5. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Mordes DA, et al. Acta Neuropathol Commun, 2018 Jul 4. PMID 29973287, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An evolutionarily conserved protein CHORD (morgana) regulates scaling of dendritic arbors with body size.
      Title: An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    morgana
    Names
    CG6198-PA
    CHORD
    CHORD containing protein
    mora-PA
    morgana/chp-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24186359..24187785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142969.4 → NP_651226.1  morgana [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651226.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4A3, Q9VCC0
      Related
      FBpp0083939
      Conserved Domains (2) summary
      cd06488
      Location:213 → 301
      p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
      pfam04968
      Location:3 → 63
      CHORD; CHORD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCC0.1 Q9VCC0

    Gene LinkOut

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