Cndp2 Cytosolic non-specific dipeptidase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cndp2provided by FlyBase
Official Full Name: Cytosolic non-specific dipeptidase 2provided by FlyBase
Primary source: FLYBASE:FBgn0287767
Locus tag: Dmel_CG17337
See related: AllianceGenome:FB:FBgn0287767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-41Fb; CG17337; CN; CNDP; dcndp; dCNDP2; Dip; Dip-A; DipA; Dm52; Dmel\CG17337; Y
Summary: Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol and nucleus. Is expressed in several structures, including adult head; embryonic/larval crystal cell; embryonic/larval midgut primordium; embryonic/larval salivary gland; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 41F8-41F8; 2-55 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (5697872..5700212)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1585377..1587717)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of CNDP causes a shorter lifespan and higher sensitivity to oxidative stress in Drosophila melanogaster.
Title: Loss of CNDP causes a shorter lifespan and higher sensitivity to oxidative stress in Drosophila melanogaster.
CNDP2 gene, CG17337, Study demonstrates that only one of the two predicted dCNDP2 isoforms is expressed throughout the different tissues tested. dCNDP2 was detected in both the cytoplasm and the nucleus, and was found to be associated with multiple sites in the salivary gland polytene chromosomes.
Title: A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytosolic non-specific dipeptidase 2

Names: CG17337-PA; CG17337-PC; Cndp2-PA; Cndp2-PC; Dipeptidase-A; anon-41Fb; carnosinase; carnosine dipeptidase 2; dipeptidase A; transcription unit Y

NP_001286142.1

EC 3.-.-.-

EC 3.4.-.-

NP_610181.2

EC 3.-.-.-

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

5697872..5700212

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136337.3 → NP_610181.2 cytosolic non-specific dipeptidase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610181.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8MT58

Related

FBpp0085374

Conserved Domains (2) summary

PRK08201
Location:8 → 475

PRK08201; hypothetical protein; Provisional

cd05676
Location:11 → 478

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
NM_001299213.1 → NP_001286142.1 cytosolic non-specific dipeptidase 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286142.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LEQ0

Conserved Domains (2) summary

cd05676
Location:1 → 431

M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

COG0624
Location:1 → 431

ArgE; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase [Amino acid transport and metabolism]