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    siz schizo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sizprovided by FlyBase
    Official Full Name
    schizoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026179
    Locus tag
    Dmel_CG32434
    See related
    AllianceGenome:FB:FBgn0026179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10577; CG12980; CG12981; CG32434; Dmel\CG32434; loner; Loner; Schizo; Siz
    Summary
    Enables cadherin binding activity. Involved in several processes, including actin cytoskeleton organization; compound eye morphogenesis; and myoblast fusion. Predicted to be located in Golgi membrane. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; brain; head epidermis primordium; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities; lung adenocarcinoma; and non-syndromic X-linked intellectual disability 1. Orthologous to several human genes including IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See siz in Genome Data Viewer
    Location:
    78A5-78B1; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21034535..21075444)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21027635..21068544)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45945

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo. Lübke S, et al. Biol Open, 2024 Jan 15. PMID 34897417, Free PMC Article
    2. Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature. Ansar M, et al. Am J Hum Genet, 2019 Nov 7. PMID 31607425, Free PMC Article
    3. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Casanova JE. Traffic, 2007 Nov. PMID 17850229
    4. Myoblasts fuse when loner meets ARF6. Donaldson JG. Dev Cell, 2003 Oct. PMID 14536050
    5. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Cox R, et al. Mol Biol Cell, 2004 Apr. PMID 14742722, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
      Title: The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
    2. Results suggest that N-cadherin is regulated in a Schizo/Loner- and d-Arf1-dependent manner.
      Title: The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts.
    3. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
      Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cadherin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ARF protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    schizo
    Names
    CG32434-PA
    CG32434-PB
    CG32434-PC
    CG32434-PD
    dBRAG
    loner
    siz-PA
    siz-PB
    siz-PC
    siz-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21034535..21075444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168881.3 → NP_730594.1  schizo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730594.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U159, Q9VP80
      Related
      FBpp0077947
      Conserved Domains (2) summary
      cd13318
      Location:981 → 1108
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:766 → 954
      Sec7; Sec7 domain

    2. NM_001170016.1 → NP_001163487.1  schizo, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI59, Q5U112
      Conserved Domains (2) summary
      cd13318
      Location:876 → 1003
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:661 → 849
      Sec7; Sec7 domain

    3. NM_206407.2 → NP_996129.1  schizo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U112, Q7KTX2
      Conserved Domains (2) summary
      cd13318
      Location:969 → 1096
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:754 → 942
      Sec7; Sec7 domain

    4. NM_001043153.2 → NP_001036618.1  schizo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U112, Q6U9V3
      Conserved Domains (2) summary
      cd13318
      Location:866 → 993
      PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain
      pfam01369
      Location:651 → 839
      Sec7; Sec7 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI59 E1JI59
    Q5U112 Q5U112
    Q5U159 Q5U159
    Q6U9V3 Q6U9V3
    Q7KTX2 Q7KTX2
    Q95U36 Q95U36
    Q9VP80 Q9VP80

    Gene LinkOut

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