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    CG1578 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1578provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030336
    Locus tag
    Dmel_CG1578
    See related
    AllianceGenome:FB:FBgn0030336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1578
    Summary
    Predicted to enable diphthine-ammonia ligase activity. Predicted to be involved in protein histidyl modification to diphthamide. Orthologous to human DPH6 (diphthamine biosynthesis 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1578 in Genome Data Viewer
    Location:
    10E5-10E6; 1-36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11808506..11816551, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11702539..11710584, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Casein kinase II beta subunit Neighboring gene Heat shock protein 70 cognate 3 Neighboring gene rudhira Neighboring gene antisense RNA:CR43908 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster. Lundberg LE, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733888, Free PMC Article
    2. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
    3. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Miozzo F, et al. Nat Commun, 2022 Mar 17. PMID 35301315, Free PMC Article
    4. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article
    5. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Legube G, et al. Genes Dev, 2006 Apr 1. PMID 16547175, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diphthine-ammonia ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphthine-ammonia ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1578-PA
    CG1578-PB
    CG1578-PC
    NP_001285140.1
    NP_001285141.1
    NP_572749.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11808506..11816551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298212.1 → NP_001285141.1  uncharacterized protein Dmel_CG1578, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285141.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRI4, Q9VYU1
      Conserved Domains (3) summary
      cd06155
      Location:465 → 561
      eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
      cd06156
      Location:610 → 716
      eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
      cd01994
      Location:2 → 211
      Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

    2. NM_132521.3 → NP_572749.2  uncharacterized protein Dmel_CG1578, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572749.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRI4, Q9VYU1
      Conserved Domains (3) summary
      cd06155
      Location:465 → 561
      eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
      cd06156
      Location:610 → 716
      eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
      cd01994
      Location:2 → 211
      Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...

    3. NM_001298211.1 → NP_001285140.1  uncharacterized protein Dmel_CG1578, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285140.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MRI4, Q9VYU1
      Conserved Domains (3) summary
      cd06155
      Location:465 → 561
      eu_AANH_C_1; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these ...
      cd06156
      Location:610 → 716
      eu_AANH_C_2; A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these ...
      cd01994
      Location:2 → 211
      Alpha_ANH_like_IV; This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRI4 Q8MRI4

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