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    DNAlig1 DNA ligase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37791, updated on 17-Dec-2024

    Summary

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    Official Symbol
    DNAlig1provided by FlyBase
    Official Full Name
    DNA ligase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262619
    Locus tag
    Dmel_CG5602
    See related
    AllianceGenome:FB:FBgn0262619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5602; dDNAlig1; Dlig-I; DmDNA Lig I; Dmel\CG5602; DNA-lig1; DNA-ligI; LIG1
    Summary
    Enables DNA ligase (ATP) activity. Predicted to be involved in DNA ligation and Okazaki fragment processing involved in mitotic DNA replication. Located in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DNAlig1 in Genome Data Viewer
    Location:
    60A8-60A8; 2-105 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23890512..23893177)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19778035..19780700)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Putative homeodomain protein Neighboring gene uncharacterized protein Neighboring gene Decapping protein 1 Neighboring gene Upf3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lost PHDs of trr

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA ligase from Drosophila melanogaster embryos. Purification and physical characterization. Rabin BA, et al. J Biol Chem, 1986 Aug 15. PMID 3090038
    2. DNA ligase from Drosophila melanogaster embryos. Substrate specificity and mechanism of action. Rabin BA, et al. J Biol Chem, 1987 Oct 15. PMID 3115985
    3. Eukaryotic DNA ligases. Lasko DD, et al. Mutat Res, 1990 Sep-Nov. PMID 2204827
    4. Two distinct DNA ligases from Drosophila melanogaster embryos. Takahashi M, et al. FEBS Lett, 1987 Mar 23. PMID 3104089
    5. Asymmetric histone inheritance via strand-specific incorporation and biased replication fork movement. Wooten M, et al. Nat Struct Mol Biol, 2019 Aug. PMID 31358945, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA ligase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Okazaki fragment processing involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA ligase 1
    Names
    CG5602-PA
    DNA ligase I
    DNAlig1-PA
    NP_611843.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23890512..23893177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137999.3 → NP_611843.2  DNA ligase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611843.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960P4, Q9W1H4
      Related
      FBpp0072041
      Conserved Domains (4) summary
      cd07969
      Location:581 → 726
      OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
      cd07900
      Location:358 → 576
      Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
      PLN03113
      Location:1 → 745
      PLN03113; DNA ligase 1; Provisional
      pfam04675
      Location:126 → 292
      DNA_ligase_A_N; DNA ligase N terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1H4.2 Q9W1H4

    Gene LinkOut

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