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    inaF-D inaF-D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inaF-Dprovided by FlyBase
    Official Full Name
    inaF-Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260812
    Locus tag
    Dmel_CG42563
    See related
    AllianceGenome:FB:FBgn0260812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.148; CG2457; CG42563; Dmel\CG42563; inaF; InaF; INAF
    Old locus tag
    Dmel_CG2457
    Summary
    Predicted to enable channel regulator activity. Predicted to be involved in regulation of membrane potential. Predicted to be located in membrane. Is expressed in eye and head. Orthologous to human INAFM2 (InaF motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See inaF-D in Genome Data Viewer
    Location:
    10D8-10E1; 1-35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11724668..11729099, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11618701..11623132, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pretaporter Neighboring gene Transport and Golgi organization 10 Neighboring gene uncharacterized protein Neighboring gene inaF-B Neighboring gene inaF-C Neighboring gene inaF-A Neighboring gene pseudo Neighboring gene miniature Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Visual mutations reveal opposing effects of illumination on arousal in Drosophila. Cheng Y, et al. Genetics, 2008 Apr. PMID 18430958, Free PMC Article
    2. Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Cheng Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17968007, Free PMC Article
    3. INAF, a protein required for transient receptor potential Ca(2+) channel function. Li C, et al. Proc Natl Acad Sci U S A, 1999 Nov 9. PMID 10557345, Free PMC Article
    4. Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Rosenzweig M, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18787131, Free PMC Article
    5. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. Meyer NE, et al. J Cell Sci, 2006 Jun 15. PMID 16735439, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. INAF-B gene product is an integral membrane protein that colocalizes to rhabdomeres along with TRP channels.
      Title: Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inaF-D
    Names
    CG42563-PB
    inaF
    inaF-D-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11724668..11729099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103488.2 → NP_001096958.1  inaF-D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096958.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUS1
      Conserved Domains (1) summary
      pfam15018
      Location:31 → 64
      InaF-motif; TRP-interacting helix
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUS1 A8JUS1
    Q7KAJ6 Q7KAJ6
    Q95RZ0 Q95RZ0

    Gene LinkOut

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