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    CG10588 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10588provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037037
    Locus tag
    Dmel_CG10588
    See related
    AllianceGenome:FB:FBgn0037037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10588
    Summary
    Predicted to enable protein folding chaperone. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in mitochondrial matrix. Is expressed in spermatozoon. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10588 in Genome Data Viewer
    Location:
    78A1-78A1; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20956934..20960660)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20950034..20953760)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45243 Neighboring gene Seminase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila. Pi H, et al. J Biomed Sci, 2011 Jun 17. PMID 21682860, Free PMC Article
    2. Differential gene expression related to Nora virus infection of Drosophila melanogaster. Cordes EJ, et al. Virus Res, 2013 Aug. PMID 23603562, Free PMC Article
    3. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Dai H, et al. Gene, 2006 Dec 30. PMID 17101240
    4. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article
    5. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10588-PA
    CG10588-PB
    NP_001287135.1
    NP_649271.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20956934..20960660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300206.1 → NP_001287135.1  uncharacterized protein Dmel_CG10588, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDT7, Q9VP94
      Conserved Domains (4) summary
      COG1025
      Location:27 → 980
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:85 → 214
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:244 → 419
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:436 → 720
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    2. NM_141014.2 → NP_649271.1  uncharacterized protein Dmel_CG10588, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDT7, Q9VP94
      Related
      FBpp0077942
      Conserved Domains (4) summary
      COG1025
      Location:27 → 980
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:85 → 214
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:244 → 419
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:436 → 720
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP94 Q9VP94

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