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    Sp1 Sp1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sp1provided by FlyBase
    Official Full Name
    Sp1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020378
    Locus tag
    Dmel_CG1343
    See related
    AllianceGenome:FB:FBgn0020378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1343; D-Sp1; D-Sp8; D.Sp1; Dmel\CG1343; dSp1; sp1; SP1
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including female germline cell; ganglia; imaginal disc; imaginal disc primordium; and presumptive embryonic/larval peripheral nervous system. Orthologous to several human genes including SP9 (Sp9 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sp1 in Genome Data Viewer
    Location:
    9A1-9A1; 1-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9729648..9756369)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9623681..9650402)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene buttonhead Neighboring gene long non-coding RNA:CR43498 Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase-related protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. buttonhead and D-Sp1: a novel Drosophila gene pair. Wimmer EA, et al. Mech Dev, 1996 Sep. PMID 8892232
    2. Sp1 modifies leg-to-wing transdetermination in Drosophila. Ing T, et al. Dev Biol, 2013 Jan 15. PMID 23165292, Free PMC Article
    3. Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters. Borovsky D, et al. Biomolecules, 2022 Jul 16. PMID 35883546, Free PMC Article
    4. Tiny RNAs associated with transcription start sites in animals. Taft RJ, et al. Nat Genet, 2009 May. PMID 19377478
    5. Common and diverged functions of the Drosophila gene pair D-Sp1 and buttonhead. Schöck F, et al. Mech Dev, 1999 Dec. PMID 10559487

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
      Title: In vivo analysis of the evolutionary conserved BTD-box domain of Sp1 and Btd during Drosophila development.
    2. Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
      Title: Differential Contributions of DNA-Binding Proteins to Polycomb Response Element Activity at the Drosophila giant Gene.
    3. These studies establish a role for Sp1 in leg-to-wing transdetermination.
      Title: Sp1 modifies leg-to-wing transdetermination in Drosophila.
    4. By simultaneously removing the function of two Sp8 orthologs, buttonhead (btd) and Sp1, during Drosophila embryogenesis, we find that adult leg development is completely abolished.
      Title: Non-redundant selector and growth-promoting functions of two sister genes, buttonhead and Sp1, in Drosophila leg development.
    5. Results show that buttonhead and Sp1 induce the formation and are required for the growth of the ventral imaginal discs.
      Title: The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sp1
    Names
    CG1343-PB
    CG1343-PD
    CG1343-PE
    CG1343-PF
    Sp1-PB
    Sp1-PD
    Sp1-PE
    Sp1-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9729648..9756369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132351.3 → NP_572579.3  Sp1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572579.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY21
      Conserved Domains (3) summary
      sd00017
      Location:395 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:450 → 472
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:436 → 459
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001103457.4 → NP_001096927.2  Sp1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096927.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUN6
      Conserved Domains (3) summary
      sd00017
      Location:390 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:445 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:431 → 454
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001272459.1 → NP_001259388.1  Sp1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJG1
      Conserved Domains (3) summary
      sd00017
      Location:390 → 409
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:445 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:431 → 454
      zf-H2C2_2; Zinc-finger double domain

    4. NM_167200.4 → NP_727360.1  Sp1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ80, Q8IRM5
      Related
      FBpp0071316
      Conserved Domains (3) summary
      sd00017
      Location:195 → 214
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:250 → 272
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:236 → 259
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUN6 A8JUN6
    M9PJG1 M9PJG1
    Q8IRM5 Q8IRM5
    Q9U1K4 Q9U1K4
    R9PY21 R9PY21

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