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    Eogt EGF-domain O-GlcNAc transferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eogtprovided by FlyBase
    Official Full Name
    EGF-domain O-GlcNAc transferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264672
    Locus tag
    Dmel_CG9867
    See related
    AllianceGenome:FB:FBgn0264672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9867; Dmel\CG9867; eogt; EOGT
    Summary
    Enables protein O-acetylglucosaminyltransferase activity. Involved in larval chitin-based cuticle development and protein O-GlcNAcylation via threonine. Located in endoplasmic reticulum lumen. Is expressed in embryonic/larval garland cell; garland cell primordium; and organism. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eogt in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2381097..2383073)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2381097..2383073)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44982 Neighboring gene uncharacterized protein Neighboring gene Ataxin 7 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-acetylglucosamine modification in the lumen of the endoplasmic reticulum. Ogawa M, et al. Biochim Biophys Acta, 2015 Jun. PMID 25791024
    2. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. Harvey BM, et al. J Biol Chem, 2016 Jul 29. PMID 27268051, Free PMC Article
    3. Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease. Ogawa M, et al. World J Biol Chem, 2014 May 26. PMID 24921011, Free PMC Article
    4. O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Sakaidani Y, et al. Nat Commun, 2011 Dec 13. PMID 22158438
    5. EOGT and O-GlcNAc on secreted and membrane proteins. Varshney S, et al. Biochem Soc Trans, 2017 Apr 15. PMID 28408480, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-GlcNAcylation via threonine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-GlcNAcylation via threonine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EGF-domain O-GlcNAc transferase
    Names
    CG9867-PA
    CG9867-PB
    EGF-domain specific O-GlcNAc transferase
    Eogt-PA
    Eogt-PB
    NP_001259934.1
    NP_608678.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2381097..2383073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134834.3 → NP_608678.1  EGF-domain O-GlcNAc transferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQB7
      UniProtKB/TrEMBL
      M9PBV8
      Related
      FBpp0077447
      Conserved Domains (1) summary
      pfam04577
      Location:232 → 454
      DUF563; Protein of unknown function (DUF563)

    2. NM_001273005.1 → NP_001259934.1  EGF-domain O-GlcNAc transferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQB7
      UniProtKB/TrEMBL
      M9PBV8
      Conserved Domains (1) summary
      pfam04577
      Location:232 → 454
      DUF563; Protein of unknown function (DUF563)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBV8 M9PBV8
    Q9VQB7.1 Q9VQB7

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