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    Hexo1 Hexosaminidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38528, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hexo1provided by FlyBase
    Official Full Name
    Hexosaminidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0041630
    Locus tag
    Dmel_CG1318
    See related
    AllianceGenome:FB:FBgn0041630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1318; Dmel\CG1318; DmHex1; HEX 1; HEX1; HEXO1
    Summary
    Enables beta-N-acetylglucosaminidase activity. Involved in N-glycan processing and rhodopsin biosynthetic process. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; gut section; and larval imaginal tissue. Human ortholog(s) of this gene implicated in Sandhoff disease; Tay-Sachs disease; and spinal muscular atrophy. Orthologous to human HEXA (hexosaminidase subunit alpha) and HEXB (hexosaminidase subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hexo1 in Genome Data Viewer
    Location:
    64A12-64A12; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4288641..4291211)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4288641..4291211)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Transcription factor IIEbeta Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 2 Neighboring gene dusky-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Demonstration of beta-N-acetyl-D-glucosaminidase and beta-N-acetyl-D-hexosaminidase in Drosophila Kc-cells. Sommer U, et al. Arch Insect Biochem Physiol, 1991. PMID 1834255
    2. Physical properties of beta-N-acetyl-D-glucosaminidase and beta-N-acetyl-D-hexosaminidase from Drosophila Kc-cells. Sommer U, et al. Arch Insect Biochem Physiol, 1991. PMID 1834256
    3. The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing. Léonard R, et al. J Biol Chem, 2006 Feb 24. PMID 16339150
    4. Interspecific analysis of the glycosidases of the sperm plasma membrane in Drosophila. Intra J, et al. Mol Reprod Dev, 2009 Jan. PMID 18484570
    5. Male sterile mutant casanova gives clues to mechanisms of sperm-egg interactions in Drosophila melanogaster. Perotti ME, et al. Mol Reprod Dev, 2001 Oct. PMID 11553926

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. purification and characterization of hexosaminidase 1 from spermatozoa plasma membrane
      Title: Purification and characterization of the plasma membrane glycosidases of Drosophila melanogaster spermatozoa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-N-acetylglucosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-N-acetylglucosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosaminoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hexosaminidase 1
    Names
    CG1318-PA
    CG1318-PD
    CG1318-PE
    CG1318-PF
    Hexo1-PA
    Hexo1-PD
    Hexo1-PE
    Hexo1-PF
    NP_523924.1
    NP_728974.2
    NP_728975.1
    NP_728976.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4288641..4291211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168076.2 → NP_728975.1  hexosaminidase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRB6, Q8MSS9
      Related
      FBpp0073093
      Conserved Domains (2) summary
      cd06562
      Location:214 → 579
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:69 → 190
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    2. NM_168077.3 → NP_728976.2  hexosaminidase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728976.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRB6, Q8MSS9
      Conserved Domains (2) summary
      cd06562
      Location:214 → 579
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:69 → 190
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    3. NM_079200.5 → NP_523924.1  hexosaminidase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8H9, Q8MSS9
      Related
      FBpp0073091
      Conserved Domains (2) summary
      cd06562
      Location:214 → 579
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:69 → 190
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    4. NM_168075.2 → NP_728974.2  hexosaminidase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728974.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRB6, Q8MSS9
      Conserved Domains (2) summary
      cd06562
      Location:214 → 579
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:69 → 190
      Glycohydro_20b2; beta-acetyl hexosaminidase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8H9 Q0E8H9
    Q8IRB6 Q8IRB6
    Q8MSS9 Q8MSS9
    Q95S03 Q95S03

    Gene LinkOut

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