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    CG6833 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6833provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036405
    Locus tag
    Dmel_CG6833
    See related
    AllianceGenome:FB:FBgn0036405
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6833; REXO4
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in DNA catabolic process and RNA processing. Predicted to be active in nucleus. Is expressed in organism and spermatozoon. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6833 in Genome Data Viewer
    Location:
    70D1-70D1; 3-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14051206..14052469)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14044306..14045569)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Heat shock protein 110 Neighboring gene Neuralized E3 ubiquitin protein ligase 4 Neighboring gene antisense RNA:CR46067 Neighboring gene uncharacterized protein Neighboring gene Formin-like Neighboring gene Peroxin 1 Neighboring gene breathless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurl4 contributes to germ cell formation and integrity in Drosophila. Jones J, et al. Biol Open, 2015 Jun 26. PMID 26116656, Free PMC Article
    2. Unique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila. Dollar G, et al. Genetics, 2016 Mar. PMID 26801180, Free PMC Article
    3. The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs. Gerstberger S, et al. Cell Rep, 2017 Oct 17. PMID 29045842, Free PMC Article
    4. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article
    5. The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Han BW, et al. Curr Biol, 2011 Nov 22. PMID 22055293, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6833-PA
    CG6833-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14051206..14052469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140432.5 → NP_648689.1  uncharacterized protein Dmel_CG6833, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC3
      Related
      FBpp0075516
      Conserved Domains (2) summary
      cd06144
      Location:118 → 270
      REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
      COG0847
      Location:100 → 283
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

    2. NM_001202176.2 → NP_001189105.1  uncharacterized protein Dmel_CG6833, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUC3
      Conserved Domains (2) summary
      cd06144
      Location:118 → 270
      REX4_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins
      COG0847
      Location:100 → 283
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUC3 Q9VUC3

    Gene LinkOut

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