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    koi klaroid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    koiprovided by FlyBase
    Official Full Name
    klaroidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265003
    Locus tag
    Dmel_CG44154
    See related
    AllianceGenome:FB:FBgn0265003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD11166; CG18584; CG3287; CG44154; Dmel\CG44154; Koi; n(2)09967
    Old locus tag
    Dmel_CG18584; Dmel_CG3287
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in double-strand break repair via homologous recombination and nuclear migration. Located in nuclear envelope; nuclear periphery; and perinuclear region of cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See koi in Genome Data Viewer
    Location:
    42D4-42D4; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6811019..6818199)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2698524..2705704)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Succinate dehydrogenase, subunit B (iron-sulfur) Neighboring gene uncharacterized protein Neighboring gene ubiquitin like Neighboring gene long non-coding RNA:CR44442 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LINC Complex Inhibits Excessive Chromatin Repression. Amiad Pavlov D, et al. Cells, 2023 Mar 18. PMID 36980273, Free PMC Article
    2. Mixing and Matching Chromosomes during Female Meiosis. Rubin T, et al. Cells, 2020 Mar 12. PMID 32178277, Free PMC Article
    3. Nucleus-dependent sarcomere assembly is mediated by the LINC complex. Auld AL, et al. Mol Biol Cell, 2016 Aug 1. PMID 27307582, Free PMC Article
    4. Drosophila emerins control LINC complex localization and transcription to regulate myonuclear position. Mandigo TR, et al. J Cell Sci, 2019 Oct 18. PMID 31548202
    5. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import. Commisso C, et al. J Mol Biol, 2008 Jan 25. PMID 18076903

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that mushroom body defect protein (Mud) co-localized with centromeres, Klarsicht protein and Klaroid protein.
      Title: Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.
    2. Germ line nuclear envelope localization of both Msp-100 and Klarsicht proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females.
      Title: The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis.
    3. Klaroid, a SUN protein that tethers klarsitch, is identified. Both klaroid and klarsicht are required for nuclear migration in differentiating neurons and in non-neural cells.
      Title: Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    klaroid
    Names
    CG44154-PA
    CG44154-PB
    CG44154-PC
    CG44154-PD
    CG44154-PE
    CG44154-PF
    koi-PA
    koi-PB
    koi-PC
    koi-PD
    koi-PE
    koi-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6811019..6818199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273809.1 → NP_001260738.1  klaroid, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KEE4
      Conserved Domains (1) summary
      pfam07738
      Location:827 → 962
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. NM_165491.3 → NP_724502.1  klaroid, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Q0, Q8MS42

    3. NM_001273810.1 → NP_001260739.1  klaroid, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260739.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KEE4
      Conserved Domains (1) summary
      pfam07738
      Location:827 → 962
      Sad1_UNC; Sad1 / UNC-like C-terminal

    4. NM_001273811.1 → NP_001260740.1  klaroid, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Q0, Q8MS42

    5. NM_136396.4 → NP_610240.4  klaroid, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610240.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Q1
      Conserved Domains (1) summary
      pfam07738
      Location:743 → 878
      Sad1_UNC; Sad1 / UNC-like C-terminal

    6. NM_165492.3 → NP_724503.2  klaroid, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724503.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZ58
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEE4.1 A0A0B4KEE4
    A1Z6Q0 A1Z6Q0
    A1Z6Q1 A1Z6Q1
    A4UZ58 A4UZ58
    Q8MS42 Q8MS42

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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