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    Polr3E RNA polymerase III subunit E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3Eprovided by FlyBase
    Official Full Name
    RNA polymerase III subunit Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028402
    Locus tag
    Dmel_CG10582
    See related
    AllianceGenome:FB:FBgn0028402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10582; Dmel\CG10582; RPC37; sin; Sin
    Summary
    Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Is expressed in organism. Used to study chromosome 16p12.1 deletion syndrome. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr3E in Genome Data Viewer
    Location:
    78A5-78A5; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21031825..21033561)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21024925..21026661)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45801 Neighboring gene uncharacterized protein Neighboring gene Decaprenyl diphosphate synthase subunit 2 Neighboring gene uncharacterized protein Neighboring gene schizo Neighboring gene uncharacterized protein Neighboring gene knockout Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. Dong Z, et al. Gene, 1999 Sep 17. PMID 10521666
    2. Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. Pizzo L, et al. PLoS Genet, 2021 Apr. PMID 33819264, Free PMC Article
    3. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    4. Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway. Fisher KH, et al. BMC Genomics, 2012 Sep 24. PMID 23006893, Free PMC Article
    5. A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability. Fisher KH, et al. J Cell Sci, 2018 Jul 6. PMID 29848658, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase III subunit E
    Names
    CG10582-PA
    CG10582-PC
    Polr3E-PA
    Polr3E-PC
    Sex-lethal interactor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21031825..21033561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170015.2 → NP_001163486.2  RNA polymerase III subunit E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163486.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI58, Q9U778
      Conserved Domains (1) summary
      pfam04801
      Location:9 → 443
      Sin_N; Sin-like protein conserved region

    2. NM_079468.4 → NP_524192.2  RNA polymerase III subunit E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524192.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U778, Q9VP85
      Related
      FBpp0077946
      Conserved Domains (1) summary
      pfam04801
      Location:4 → 444
      Sin_N; Sin-like protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JI58 E1JI58
    Q5BI58 Q5BI58
    Q9U778 Q9U778
    Q9VP85 Q9VP85

    Gene LinkOut

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