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    Sfmbt Scm-related gene containing four mbt domains [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sfmbtprovided by FlyBase
    Official Full Name
    Scm-related gene containing four mbt domainsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032475
    Locus tag
    Dmel_CG16975
    See related
    AllianceGenome:FB:FBgn0032475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16975; Dmel\CG16975; dSfmbt; dSFMBT; sfmbt; SFMBT
    Summary
    Enables chromatin binding activity and methylated histone binding activity. Involved in heterochromatin formation; imaginal disc growth; and oogenesis. Located in nucleus. Part of PcG protein complex. Is expressed in several structures, including embryonic central brain neurons; embryonic/larval midgut; ganglia; larval nervous system; and ventral ectoderm. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sfmbt in Genome Data Viewer
    Location:
    34A7-34A8; 2-47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13169649..13176785, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13169649..13176785, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kumgang Neighboring gene DnaJ homolog Neighboring gene Sirtuin 1 Neighboring gene antisense RNA:CR46256 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combinatorial interactions are required for the efficient recruitment of pho repressive complex (PhoRC) to polycomb response elements. Kahn TG, et al. PLoS Genet, 2014 Jul. PMID 25010632, Free PMC Article
    2. MBT domain proteins in development and disease. Bonasio R, et al. Semin Cell Dev Biol, 2010 Apr. PMID 19778625, Free PMC Article
    3. A Novel PRE-Element from Drosophila virilis Genome as a Useful Model Silencer. Chetverina DA, et al. Dokl Biochem Biophys, 2019 May. PMID 31012008
    4. Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. Grimm C, et al. EMBO Rep, 2007 Nov. PMID 17932512, Free PMC Article
    5. Transcription through enhancers suppresses their activity in Drosophila. Erokhin M, et al. Epigenetics Chromatin, 2013 Sep 26. PMID 24279291, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PcG protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scm-related gene containing four mbt domains
    Names
    CG16975-PA
    CG16975-PB
    CG16975-PC
    CG16975-PD
    Sfmbt-PA
    Sfmbt-PB
    Sfmbt-PC
    Sfmbt-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13169649..13176785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165026.2 → NP_723786.1  Scm-related gene containing four mbt domains, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VK33
      Related
      FBpp0080069
      Conserved Domains (4) summary
      cd09580
      Location:785 → 851
      SAM_Scm-like-4MBT; SAM domain of Scm-like-4MBT proteins of Polycomb group
      smart00454
      Location:785 → 849
      SAM; Sterile alpha motif
      smart00561
      Location:530 → 623
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam16031
      Location:623 → 688
      TonB_N; TonB N-terminal region

    2. NM_135762.3 → NP_609606.2  Scm-related gene containing four mbt domains, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609606.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KTB5, Q9VK32, Q9VK33
      UniProtKB/TrEMBL
      M9PFS7
      Related
      FBpp0080070
      Conserved Domains (4) summary
      cd09580
      Location:1137 → 1203
      SAM_Scm-like-4MBT; SAM domain of Scm-like-4MBT proteins of Polycomb group
      smart00454
      Location:1137 → 1201
      SAM; Sterile alpha motif
      smart00561
      Location:882 → 975
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam16031
      Location:975 → 1040
      TonB_N; TonB N-terminal region

    3. NM_001144349.2 → NP_001137821.1  Scm-related gene containing four mbt domains, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZV6
      Conserved Domains (4) summary
      cd09580
      Location:1160 → 1226
      SAM_Scm-like-4MBT; SAM domain of Scm-like-4MBT proteins of Polycomb group
      smart00454
      Location:1160 → 1224
      SAM; Sterile alpha motif
      smart00561
      Location:882 → 975
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam16031
      Location:975 → 1040
      TonB_N; TonB N-terminal region

    4. NM_001273503.1 → NP_001260432.1  Scm-related gene containing four mbt domains, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260432.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KTB5, Q9VK32, Q9VK33
      UniProtKB/TrEMBL
      M9PFS7
      Conserved Domains (4) summary
      cd09580
      Location:1137 → 1203
      SAM_Scm-like-4MBT; SAM domain of Scm-like-4MBT proteins of Polycomb group
      smart00454
      Location:1137 → 1201
      SAM; Sterile alpha motif
      smart00561
      Location:882 → 975
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam16031
      Location:975 → 1040
      TonB_N; TonB N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZV6 B7YZV6
    M9PFS7 M9PFS7
    Q9VK33.2 Q9VK33

    Gene LinkOut

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