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    Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35943, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Gnptabprovided by FlyBase
    Official Full Name
    N-acetylglucosamine-1-phosphate transferase subunits alpha and betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033392
    Locus tag
    Dmel_CG8027
    See related
    AllianceGenome:FB:FBgn0033392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg8027; CG8027; Dmel\CG8027; DmGNPTAB; GNPTAB; Gntap
    Summary
    Predicted to enable UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. Predicted to be involved in N-glycan processing to lysosome. Predicted to be active in Golgi membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in mucolipidosis II alpha/beta and mucolipidosis III alpha/beta. Orthologous to human GNPTAB (N-acetylglucosamine-1-phosphate transferase subunits alpha and beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gnptab in Genome Data Viewer
    Location:
    45B3-45B4; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9204410..9207124, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5091915..5094629, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unplugged Neighboring gene Vacuolar H[+] ATPase AC45 accessory subunit Neighboring gene long non-coding RNA:CR45309

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport. Du S, et al. J Biol Chem, 2022 Mar. PMID 35148990, Free PMC Article
    2. Structure of a truncated human GlcNAc-1-phosphotransferase variant reveals the basis for its hyperactivity. Li H, et al. J Biol Chem, 2024 Sep. PMID 39178950, Free PMC Article
    3. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. Yu M, et al. PLoS Genet, 2023 May. PMID 37200393, Free PMC Article
    4. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. Asensio CS, et al. J Cell Biol, 2010 Dec 13. PMID 21149569, Free PMC Article
    5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing to lysosome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
    Names
    CG8027-PA
    Gnptab-PA
    NP_610469.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9204410..9207124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136625.3 → NP_610469.3  N-acetylglucosamine-1-phosphate transferase subunits alpha and beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610469.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7S7, Q8SXI4
      Related
      FBpp0087690
      Conserved Domains (5) summary
      pfam00066
      Location:206 → 240
      Notch; LNR domain
      pfam11380
      Location:93 → 200
      Stealth_CR2; Stealth protein CR2, conserved region 2
      pfam17101
      Location:64 → 90
      Stealth_CR1; Stealth protein CR1, conserved region 1
      pfam17102
      Location:374 → 422
      Stealth_CR3; Stealth protein CR3, conserved region 3
      pfam17103
      Location:561 → 616
      Stealth_CR4; Stealth protein CR4, conserved region 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7S7 A1Z7S7
    Q8SXI4 Q8SXI4

    Gene LinkOut

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