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    DopEcR Dopamine/Ecdysteroid receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38539, updated on 9-Dec-2024

    Summary

    Official Symbol
    DopEcRprovided by FlyBase
    Official Full Name
    Dopamine/Ecdysteroid receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035538
    Locus tag
    Dmel_CG18314
    See related
    AllianceGenome:FB:FBgn0035538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.139; anon-WO0170980.140; CG18314; DmDopEcR; Dmel\CG18314; dop; DopECR
    Summary
    Enables dopamine neurotransmitter receptor activity, coupled via Gs and ecdysone binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to sucrose stimulus; and learning. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; adult mushroom body; and ganglia. Used to study alcohol use disorder and renal fibrosis. Orthologous to human GPR21 (G protein-coupled receptor 21) and GPR52 (G protein-coupled receptor 52). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See DopEcR in Genome Data Viewer
    Location:
    64B2-64B3; 3-12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4367649..4380387, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4367649..4380387, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44360 Neighboring gene uncharacterized protein Neighboring gene slowdown

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in associative learning PubMed 
    involved_in behavioral response to ethanol PubMed 
    involved_in cellular response to starvation PubMed 
    involved_in cellular response to sucrose stimulus PubMed 
    involved_in habituation PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in response to ecdysone PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to starvation PubMed 
    involved_in response to sucrose PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Dopamine/Ecdysteroid receptor
    Names
    CG18314-PA
    CG18314-PB
    CG18314-PC
    DopEcR-PA
    DopEcR-PB
    DopEcR-PC
    dopamine/ecdysteroid receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4367649..4380387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014560.2 → NP_001014560.1  Dopamine/Ecdysteroid receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR64, Q8T0P6, Q9VZD1
      Conserved Domains (1) summary
      cd00637
      Location:18 → 289
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001014559.3 → NP_001014559.1  Dopamine/Ecdysteroid receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR64, Q8T0P6, Q9VZD1
      Conserved Domains (1) summary
      cd00637
      Location:18 → 289
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
    3. NM_139640.3 → NP_647897.2  Dopamine/Ecdysteroid receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647897.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MR64, Q8T0P6, Q9VZD1
      Related
      FBpp0073193
      Conserved Domains (1) summary
      cd00637
      Location:18 → 289
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
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