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    CG18809 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18809provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042132
    Locus tag
    Dmel_CG18809
    See related
    AllianceGenome:FB:FBgn0042132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1809; Dmel\CG18809
    Summary
    Predicted to enable 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in determination of adult lifespan. Orthologous to human TRIR (telomerase RNA component interacting RNase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18809 in Genome Data Viewer
    Location:
    18E5-18E5; 1-64 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19741224..19744335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19635257..19638368, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 1/2, beta subunit Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 6B Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45501 Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene parvin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Copeland JM, et al. Curr Biol, 2009 Oct 13. PMID 19747824
    2. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Gill S, et al. Science, 2015 Mar 13. PMID 25766238, Free PMC Article
    3. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    4. Drosophila nervous system as a target of aging and anti-aging interventions. Omelyanchuk LV, et al. Front Genet, 2015. PMID 25806047, Free PMC Article
    5. Targeting metabolic pathways for extension of lifespan and healthspan across multiple species. Parkhitko AA, et al. Ageing Res Rev, 2020 Dec. PMID 33031925, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18809-PA
    CG18809-PB
    CG18809-PC
    CG18809-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19741224..19744335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167682.3 → NP_728298.1  uncharacterized protein Dmel_CG18809, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R7
      Related
      FBpp0074580

    2. NM_167681.3 → NP_728297.1  uncharacterized protein Dmel_CG18809, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R7
      Related
      FBpp0074579

    3. NM_144412.4 → NP_652669.1  uncharacterized protein Dmel_CG18809, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R7

    4. NM_001272801.1 → NP_001259730.1  uncharacterized protein Dmel_CG18809, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7R7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7R7 Q9I7R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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