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    Polr3A RNA polymerase III subunit A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32524, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3Aprovided by FlyBase
    Official Full Name
    RNA polymerase III subunit Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030687
    Locus tag
    Dmel_CG17209
    See related
    AllianceGenome:FB:FBgn0030687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C160; CG17209; dC160; Dmel\CG17209; PolR3A; Rpc160; RpIIIC160; RPO31
    Summary
    Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase III activity. Involved in positive regulation of transcription by RNA polymerase III and positive regulation of translation. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr3A in Genome Data Viewer
    Location:
    13E14-13E15; 1-51 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15762956..15769514)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15656989..15663547)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene GTPase regulator associated with FAK Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Ureña E, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38241436, Free PMC Article
    2. RNA polymerase II is recruited to DNA double-strand breaks for dilncRNA transcription in Drosophila. Böttcher R, et al. RNA Biol, 2022. PMID 34965182, Free PMC Article
    3. Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Martínez Corrales G, et al. Cell Rep, 2020 Feb 11. PMID 32049000, Free PMC Article
    4. RNA polymerase III limits longevity downstream of TORC1. Filer D, et al. Nature, 2017 Dec 14. PMID 29186112, Free PMC Article
    5. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase III subunit A
    Names
    CG17209-PC
    Polr3A-PC
    RNA polymerase III subunit C160
    NP_001096987.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15762956..15769514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103517.3 → NP_001096987.2  RNA polymerase III subunit A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096987.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUY3, I0EZ84
      Conserved Domains (4) summary
      cd02736
      Location:1013 → 1353
      RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
      PRK08566
      Location:13 → 919
      PRK08566; DNA-directed RNA polymerase subunit A'; Validated
      cd02583
      Location:24 → 889
      RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain
      pfam04998
      Location:839 → 1304
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUY3 A8JUY3

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