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    kune kune-kune [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kuneprovided by FlyBase
    Official Full Name
    kune-kuneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033032
    Locus tag
    Dmel_CG1298
    See related
    AllianceGenome:FB:FBgn0033032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1298; Dmel\CG1298; Kune
    Summary
    Involved in establishment of glial blood-brain barrier; regulation of tube length, open tracheal system; and septate junction assembly. Located in membrane and pleated septate junction. Is expressed in several structures, including adult head; clypeo-labral primordium; epidermis; gland; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kune in Genome Data Viewer
    Location:
    41F6-41F6; 2-55 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5671741..5672800)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1559246..1560305)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45472 Neighboring gene uncharacterized protein Neighboring gene scarface Neighboring gene Cytosolic non-specific dipeptidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. QuBiT: a quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in the Drosophila trachea. Yang R, et al. Development, 2019 May 16. PMID 30967427, Free PMC Article
    2. Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut. MacMillan HA, et al. Sci Rep, 2017 Aug 18. PMID 28821771, Free PMC Article
    3. Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila. Yanagihashi Y, et al. J Cell Sci, 2012 Apr 15. PMID 22328496
    4. A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut. Izumi Y, et al. J Cell Sci, 2012 Oct 15. PMID 22854041
    5. Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay. DaCrema D, et al. Development, 2021 Mar 19. PMID 33658221, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
      Title: Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    NOT involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in pleated septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in septate junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in septate junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kune-kune
    Names
    CG1298-PA
    kune-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5671741..5672800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136335.3 → NP_610179.2  kune-kune [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610179.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6H0, Q8SY89
      Related
      FBpp0085373
      Conserved Domains (1) summary
      pfam13903
      Location:16 → 190
      Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z6H0 A1Z6H0
    Q8SY89 Q8SY89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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