X11Lbeta X11Lbeta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: X11Lbetaprovided by FlyBase
Official Full Name: X11Lbetaprovided by FlyBase
Primary source: FLYBASE:FBgn0052677
Locus tag: Dmel_CG32677
See related: AllianceGenome:FB:FBgn0052677
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1852; CG1861; CG32677; Dmel\CG32677; Dmint2; X11B; X11LB; x11Lbeta; X11lbeta
Summary: Involved in protein localization to membrane. Predicted to be active in cytoplasm; dendritic spine; and plasma membrane. Is expressed in larval brain; larval central nervous system; and larval ventral nerve cord. Orthologous to several human genes including APBA1 (amyloid beta precursor protein binding family A member 1) and APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 9D4-9E1; 1-32 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10627737..10710947)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10521770..10604980)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: X11Lbeta

Names: CG32677-PA; CG32677-PD; CG32677-PE; X11Lbeta-PA; X11Lbeta-PD; X11Lbeta-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

10627737..10710947

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298156.1 → NP_001285085.1 X11Lbeta, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285085.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JB44

Conserved Domains (2) summary

cd00992
Location:2037 → 2110

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:1762 → 1914

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_167239.4 → NP_727440.3 X11Lbeta, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727440.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9W2S5

Conserved Domains (2) summary

cd00992
Location:2047 → 2120

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:1770 → 1924

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
NM_001272496.2 → NP_001259425.2 X11Lbeta, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259425.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PGU7

Conserved Domains (2) summary

cd00992
Location:1974 → 2047

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:1699 → 1851

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain