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    Scamp scamp [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scampprovided by FlyBase
    Official Full Name
    scampprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040285
    Locus tag
    Dmel_CG9195
    See related
    AllianceGenome:FB:FBgn0040285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1F7; BcDNA:GM04934; CG9195; Dmel\CG9195; dmSC; dmSCAMP; Sc; SCAMP
    Summary
    Involved in long-term memory and neuromuscular synaptic transmission. Located in terminal bouton. Is expressed in adult head; larval ventral nerve cord; and motor neurons. Used to study autism spectrum disorder. Orthologous to several human genes including SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Scamp in Genome Data Viewer
    Location:
    13C3-13C3; 1-50 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15446179..15449883, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15340212..15343916, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cyclic nucleotide-gated ion channel-like Neighboring gene uncharacterized protein Neighboring gene Adenosylhomocysteinase Neighboring gene shattered

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo SCAMP5 mutation causes a neurodevelopmental disorder with autistic features and seizures. Hubert L, et al. J Med Genet, 2020 Feb. PMID 31439720
    2. The secretory carrier membrane protein family: structure and membrane topology. Hubbard C, et al. Mol Biol Cell, 2000 Sep. PMID 10982391, Free PMC Article
    3. Secretory Carrier Membrane Protein (SCAMP) deficiency influences behavior of adult flies. Zheng JC, et al. Front Cell Dev Biol, 2014. PMID 25478561, Free PMC Article
    4. ben Functions with scamp during synaptic transmission and long-term memory formation in Drosophila. Zhao H, et al. J Neurosci, 2009 Jan 14. PMID 19144841, Free PMC Article
    5. Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity. Zhang YV, et al. eNeuro, 2017 Mar-Apr. PMID 28303263, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    scamp
    Names
    CG9195-PA
    CG9195-PC
    CG9195-PD
    Scamp-PA
    Scamp-PC
    Scamp-PD
    anon-fast-evolving-1F7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15446179..15449883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272643.1 → NP_001259572.1  scamp, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHD7, Q9VXV6
      Conserved Domains (1) summary
      pfam04144
      Location:125 → 301
      SCAMP; SCAMP family

    2. NM_132795.4 → NP_573023.2  scamp, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573023.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHD7, Q9VXV6
      Related
      FBpp0073895
      Conserved Domains (1) summary
      pfam04144
      Location:125 → 301
      SCAMP; SCAMP family

    3. NM_167442.2 → NP_727850.1  scamp, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR34
      Related
      FBpp0304843
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR34 Q8IR34
    Q95S98 Q95S98
    Q9NHD7 Q9NHD7
    Q9VXV6 Q9VXV6

    Gene LinkOut

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