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    Armc3 armadillo repeat containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 70882, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Armc3provided by MGI
    Official Full Name
    armadillo repeat containing 3provided by MGI
    Primary source
    MGI:MGI:1918132
    See related
    Ensembl:ENSMUSG00000037683 AllianceGenome:MGI:1918132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921513G22Rik
    Summary
    Involved in flagellated sperm motility; ribophagy; and spermatid development. Is expressed in embryo. Orthologous to human ARMC3 (armadillo repeat containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 7.9) and lung adult (RPKM 0.2) See more
    Orthologs
    human all
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    Genomic context

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    See Armc3 in Genome Data Viewer
    Location:
    2 A3; 2 13.2 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (19203676..19315054)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (19198865..19310243)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03816 Neighboring gene predicted gene, 33592 Neighboring gene STARR-seq mESC enhancer starr_03817 Neighboring gene DiGeorge syndrome critical region gene 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03818 Neighboring gene STARR-positive B cell enhancer ABC_E5893 Neighboring gene RIKEN cDNA 4930447M23 gene Neighboring gene STARR-seq mESC enhancer starr_03820 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:19310470-19310705 Neighboring gene STARR-seq mESC enhancer starr_03823 Neighboring gene methionine sulfoxide reductase B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan KM, et al. Am J Respir Cell Mol Biol, 2006 Dec. PMID 16809635
    2. Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression. Vlangos CN, et al. PLoS Genet, 2013. PMID 23437000, Free PMC Article
    3. Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility. Lei Y, et al. Dev Cell, 2021 Aug 23. PMID 34428398
    4. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. Lugani F, et al. PLoS Genet, 2013. PMID 23437001, Free PMC Article
    5. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081083.2 → NP_001074552.1  armadillo repeat-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001074552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL929034
      Consensus CDS
      CCDS38052.1
      UniProtKB/Swiss-Prot
      A2AU72, Q8BY67
      UniProtKB/TrEMBL
      B2RWT0
      Related
      ENSMUSP00000110287.3, ENSMUST00000114640.9
      Conserved Domains (4) summary
      cd00020
      Location:145 → 259
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:152 → 230
      HEAT_2; HEAT repeats
      pfam14381
      Location:739 → 867
      EDR1; Ethylene-responsive protein kinase Le-CTR1
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]

    2. NM_001271563.1 → NP_001258492.1  armadillo repeat-containing protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL929034
      Consensus CDS
      CCDS70983.1
      UniProtKB/TrEMBL
      A2AU71, B2RWT0
      Related
      ENSMUSP00000048784.7, ENSMUST00000049255.7
      Conserved Domains (4) summary
      cd00020
      Location:145 → 259
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:152 → 230
      HEAT_2; HEAT repeats
      pfam14381
      Location:727 → 855
      EDR1; Ethylene-responsive protein kinase Le-CTR1
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]

    3. NM_001271564.1 → NP_001258493.1  armadillo repeat-containing protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001258493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AL929034, BC145013
      UniProtKB/TrEMBL
      B2RWT0, B7ZN53
      Conserved Domains (4) summary
      cd00020
      Location:145 → 259
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:152 → 230
      HEAT_2; HEAT repeats
      pfam14381
      Location:723 → 851
      EDR1; Ethylene-responsive protein kinase Le-CTR1
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]

    4. NM_001271565.1 → NP_001258494.1  armadillo repeat-containing protein 3 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame acceptor splice site and lacks two alternate in-frame exons in the coding region, one of which causes a translational frameshift, compared to variant 1. It encodes isoform 4, which has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL929034
      UniProtKB/TrEMBL
      B2RWT0
      Conserved Domains (3) summary
      cd00020
      Location:145 → 259
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:152 → 230
      HEAT_2; HEAT repeats
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      19203676..19315054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162568.1 → XP_036018461.1  armadillo repeat-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      B2RWT0
      Conserved Domains (6) summary
      smart00185
      Location:469 → 504
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:32 → 182
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:358 → 504
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:143 → 178
      Arm; Armadillo/beta-catenin-like repeat
      pfam14381
      Location:754 → 871
      EDR1; Ethylene-responsive protein kinase Le-CTR1

    2. XM_036162569.1 → XP_036018462.1  armadillo repeat-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      B2RWT0
      Conserved Domains (5) summary
      smart00185
      Location:469 → 504
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:32 → 182
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:358 → 504
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:22 → 52
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:143 → 178
      Arm; Armadillo/beta-catenin-like repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AU72.1 GenPept UniProtKB/Swiss-Prot:A2AU72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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