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    Actr2 actin related protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 66713, updated on 4-Jan-2025

    Summary

    Official Symbol
    Actr2provided by MGI
    Official Full Name
    actin related protein 2provided by MGI
    Primary source
    MGI:MGI:1913963
    See related
    Ensembl:ENSMUSG00000020152 AllianceGenome:MGI:1913963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp2; D6Ertd746e; 4921510D23Rik
    Summary
    Predicted to enable cytoskeletal protein binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; meiotic chromosome movement towards spindle pole; and meiotic cytokinesis. Located in actin cap. Is expressed in cochlea and metanephros. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 51.3), CNS E18 (RPKM 43.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Actr2 in Genome Data Viewer
    Location:
    11 A3.1; 11 12.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (20012304..20062951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (20062304..20112951, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10665 Neighboring gene sprouty-related EVH1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28762 Neighboring gene STARR-seq mESC enhancer starr_28763 Neighboring gene STARR-seq mESC enhancer starr_28769 Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene STARR-positive B cell enhancer ABC_E1412 Neighboring gene STARR-positive B cell enhancer ABC_E9359 Neighboring gene STARR-positive B cell enhancer mm9_chr11:20032933-20033234 Neighboring gene STARR-seq mESC enhancer starr_28781 Neighboring gene predicted gene, 53671 Neighboring gene predicted gene 12030

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC36604

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    contributes_to actin filament binding  
    enables actin filament binding  
    contributes_to actin filament binding  
    enables cytoskeletal protein binding  
    enables protein binding PubMed 
    enables structural constituent of cytoskeleton  
    enables structural constituent of cytoskeleton  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation  
    involved_in Arp2/3 complex-mediated actin nucleation  
    involved_in Arp2/3 complex-mediated actin nucleation  
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    acts_upstream_of_or_within asymmetric cell division PubMed 
    acts_upstream_of_or_within cellular response to type II interferon PubMed 
    acts_upstream_of_or_within cilium assembly PubMed 
    acts_upstream_of_or_within cytosolic transport PubMed 
    acts_upstream_of_or_within establishment or maintenance of cell polarity PubMed 
    acts_upstream_of_or_within meiotic cell cycle PubMed 
    acts_upstream_of_or_within meiotic chromosome movement towards spindle pole PubMed 
    acts_upstream_of_or_within meiotic cytokinesis PubMed 
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    NOT involved_in regulation of double-strand break repair via nonhomologous end joining  
    acts_upstream_of_or_within spindle localization PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex  
    part_of Arp2/3 protein complex  
    part_of Arp2/3 protein complex  
    located_in actin cap PubMed 
    is_active_in cell cortex  
    located_in cell cortex PubMed 
    located_in cell projection  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in lamellipodium  
    located_in nucleus  
    located_in nucleus  
    located_in podosome core  
    is_active_in postsynapse  
    located_in site of double-strand break  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    actin-related protein 2
    Names
    ARP2 actin-related protein 2 homolog
    actin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362899.1NP_001349828.1  actin-related protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606522, BP753259
      Conserved Domains (1) summary
      smart00268
      Location:6393
      ACTIN; Actin
    2. NM_146243.2NP_666355.1  actin-related protein 2 isoform 2

      See identical proteins and their annotated locations for NP_666355.1

      Status: VALIDATED

      Source sequence(s)
      AK032832, BE448820, BP753259, BY278998
      Consensus CDS
      CCDS24455.1
      UniProtKB/Swiss-Prot
      P61161, Q6PI31
      UniProtKB/TrEMBL
      Q5SW83
      Related
      ENSMUSP00000000137.8, ENSMUST00000000137.8
      Conserved Domains (1) summary
      smart00268
      Location:6388
      ACTIN; Actin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      20012304..20062951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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