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    Wnt5a wingless-type MMTV integration site family, member 5A [ Mus musculus (house mouse) ]

    Gene ID: 22418, updated on 14-Jan-2025

    Summary

    Official Symbol
    Wnt5aprovided by MGI
    Official Full Name
    wingless-type MMTV integration site family, member 5Aprovided by MGI
    Primary source
    MGI:MGI:98958
    See related
    Ensembl:ENSMUSG00000021994 AllianceGenome:MGI:98958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wnt-5a; 8030457G12Rik
    Summary
    Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including heart development; neuron differentiation; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including embryonic morphogenesis; morphogenesis of an epithelium; and reproductive structure development. Located in cell surface and extracellular matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in limb E14.5 (RPKM 24.5), bladder adult (RPKM 18.8) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wnt5a in Genome Data Viewer
    Location:
    14 A3; 14 16.8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (28224962..28249405)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (28504543..28527448)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene predicted gene, 53838 Neighboring gene predicted gene, 52097 Neighboring gene predicted gene, 35164 Neighboring gene ribosomal protein L5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemoattractant activity involved in axon guidance PubMed 
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables frizzled binding  
    enables frizzled binding PubMed 
    enables frizzled binding PubMed 
    enables frizzled binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables receptor tyrosine kinase-like orphan receptor binding  
    enables receptor tyrosine kinase-like orphan receptor binding  
    enables signaling receptor binding PubMed 
    enables signaling receptor binding PubMed 
    Items 1 - 25 of 258
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway PubMed 
    acts_upstream_of_or_within JNK cascade PubMed 
    acts_upstream_of_or_within Wnt signaling pathway PubMed 
    involved_in Wnt signaling pathway PubMed 
    involved_in Wnt signaling pathway  
    involved_in Wnt signaling pathway, calcium modulating pathway PubMed 
    acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway PubMed 
    involved_in Wnt signaling pathway, calcium modulating pathway  
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway PubMed 
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway PubMed 
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway PubMed 
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway  
    involved_in Wnt signaling pathway, planar cell polarity pathway PubMed 
    involved_in activation of GTPase activity PubMed 
    acts_upstream_of activation of protein kinase B activity  
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in anterior/posterior axis specification, embryo PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    involved_in atrial septum development PubMed 
    acts_upstream_of_or_within axis elongation PubMed 
    acts_upstream_of axon extension involved in axon guidance  
    involved_in axon guidance PubMed 
    involved_in axonal fasciculation PubMed 
    involved_in axonogenesis PubMed 
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    involved_in canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    acts_upstream_of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within canonical Wnt signaling pathway PubMed 
    involved_in cartilage development  
    involved_in cell fate commitment  
    acts_upstream_of_or_within cell migration PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cell-cell signaling PubMed 
    involved_in cellular response to calcium ion  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to molecule of bacterial origin PubMed 
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cellular response to type II interferon  
    acts_upstream_of_or_within cervix development PubMed 
    involved_in chemoattraction of serotonergic neuron axon PubMed 
    involved_in chemorepulsion of dopaminergic neuron axon PubMed 
    acts_upstream_of_or_within cochlea morphogenesis PubMed 
    acts_upstream_of_or_within cochlea morphogenesis PubMed 
    acts_upstream_of_or_within convergent extension PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation PubMed 
    acts_upstream_of_or_within convergent extension involved in organogenesis PubMed 
    acts_upstream_of cytokine production PubMed 
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within development of primary male sexual characteristics PubMed 
    acts_upstream_of_or_within digestive tract morphogenesis PubMed 
    involved_in dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation PubMed 
    involved_in dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within embryo development PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
    involved_in embryonic skeletal system development  
    involved_in embryonic skeletal system development  
    acts_upstream_of_or_within epithelial cell migration PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation PubMed 
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity PubMed 
    acts_upstream_of_or_within establishment of planar polarity PubMed 
    involved_in face development  
    involved_in face development  
    acts_upstream_of fibroblast growth factor receptor signaling pathway PubMed 
    involved_in genitalia development  
    acts_upstream_of_or_within heart looping PubMed 
    acts_upstream_of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation PubMed 
    acts_upstream_of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation PubMed 
    involved_in hematopoietic stem cell proliferation  
    acts_upstream_of_or_within hindgut morphogenesis PubMed 
    acts_upstream_of_or_within hypophysis morphogenesis PubMed 
    involved_in inflammatory response  
    involved_in inflammatory response  
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    involved_in keratinocyte differentiation  
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within lateral sprouting involved in mammary gland duct morphogenesis PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    acts_upstream_of_or_within lung development PubMed 
    involved_in macrophage derived foam cell differentiation  
    involved_in macrophage derived foam cell differentiation  
    acts_upstream_of_or_within male gonad development PubMed 
    acts_upstream_of_or_within mammary gland branching involved in thelarche PubMed 
    acts_upstream_of meiotic nuclear division PubMed 
    involved_in melanocyte proliferation PubMed 
    acts_upstream_of mesenchymal cell proliferation PubMed 
    acts_upstream_of_or_within mesenchymal-epithelial cell signaling PubMed 
    acts_upstream_of_or_within mesodermal to mesenchymal transition involved in gastrulation PubMed 
    involved_in midbrain development PubMed 
    involved_in midbrain development PubMed 
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within midgut development PubMed 
    involved_in modulation of chemical synaptic transmission  
    acts_upstream_of_or_within morphogenesis of an epithelium PubMed 
    acts_upstream_of_or_within negative chemotaxis  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance  
    NOT involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cell proliferation in midbrain PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of fat cell differentiation  
    involved_in negative regulation of fat cell differentiation  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway PubMed 
    involved_in negative regulation of melanin biosynthetic process PubMed 
    involved_in negative regulation of mesenchymal cell proliferation  
    involved_in negative regulation of mesenchymal cell proliferation  
    acts_upstream_of_or_within negative regulation of prostatic bud formation PubMed 
    involved_in negative regulation of synapse assembly PubMed 
    acts_upstream_of_or_within neural tube closure PubMed 
    acts_upstream_of_or_within neural tube development PubMed 
    involved_in neurogenesis PubMed 
    involved_in neuron differentiation  
    involved_in neuron projection morphogenesis PubMed 
    acts_upstream_of_or_within non-canonical Wnt signaling pathway PubMed 
    involved_in non-canonical Wnt signaling pathway PubMed 
    involved_in non-canonical Wnt signaling pathway PubMed 
    acts_upstream_of_or_within notochord morphogenesis PubMed 
    involved_in olfactory bulb interneuron development PubMed 
    acts_upstream_of_or_within paraxial mesoderm formation PubMed 
    acts_upstream_of_or_within pericardium morphogenesis PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity PubMed 
    acts_upstream_of_or_within positive regulation of JUN kinase activity PubMed 
    acts_upstream_of positive regulation of JUN kinase activity  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of T cell chemotaxis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of apoptotic signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of cartilage development PubMed 
    acts_upstream_of_or_within positive regulation of cartilage development PubMed 
    involved_in positive regulation of cell-cell adhesion  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin PubMed 
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of chemokine production  
    acts_upstream_of_or_within positive regulation of cytokine production PubMed 
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of dendrite extension  
    involved_in positive regulation of dendrite morphogenesis  
    acts_upstream_of_or_within positive regulation of endocytosis PubMed 
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation PubMed 
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of inflammatory response  
    involved_in positive regulation of interleukin-1 beta production PubMed 
    involved_in positive regulation of interleukin-1 beta production PubMed 
    involved_in positive regulation of interleukin-1 beta production PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production PubMed 
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of macrophage cytokine production  
    involved_in positive regulation of macrophage cytokine production  
    acts_upstream_of_or_within positive regulation of meiotic nuclear division PubMed 
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation PubMed 
    involved_in positive regulation of neuron projection arborization PubMed 
    involved_in positive regulation of neuron projection arborization  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of non-canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of ossification  
    involved_in positive regulation of ossification  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of protein binding PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process  
    involved_in positive regulation of protein kinase C activity  
    involved_in positive regulation of protein kinase C signaling  
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of response to cytokine stimulus  
    acts_upstream_of_or_within positive regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of thymocyte apoptotic process PubMed 
    involved_in positive regulation of timing of anagen PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway  
    involved_in positive regulation of type I interferon-mediated signaling pathway  
    involved_in positive regulation of type II interferon production PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in primary heart field specification PubMed 
    acts_upstream_of_or_within primitive streak formation PubMed 
    acts_upstream_of_or_within protein localization PubMed 
    involved_in protein localization  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis PubMed 
    acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in regulation of postsynapse organization  
    involved_in regulation of postsynapse organization  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in regulation of postsynaptic specialization assembly  
    acts_upstream_of_or_within regulation of protein localization PubMed 
    involved_in regulation of protein localization PubMed 
    involved_in regulation of synapse organization  
    involved_in regulation of synaptic signaling by nitric oxide  
    involved_in secondary heart field specification PubMed 
    involved_in secondary palate development  
    involved_in secondary palate development  
    acts_upstream_of_or_within signal transduction PubMed 
    acts_upstream_of_or_within somite development PubMed 
    acts_upstream_of_or_within somitogenesis PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of thymocyte apoptotic process PubMed 
    acts_upstream_of_or_within tube closure PubMed 
    acts_upstream_of_or_within type B pancreatic cell development PubMed 
    acts_upstream_of_or_within urinary bladder development PubMed 
    acts_upstream_of_or_within uterus development PubMed 
    acts_upstream_of_or_within vagina development PubMed 
    involved_in ventricular septum development PubMed 
    involved_in wound healing  
    involved_in wound healing  
    Items 1 - 25 of 258
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse  
    located_in cell surface PubMed 
    located_in endoplasmic reticulum lumen  
    located_in extracellular matrix PubMed 
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in postsynapse  

    General protein information

    Preferred Names
    protein Wnt-5a
    Names
    wingless-related MMTV integration site 5A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256224.2NP_001243153.1  protein Wnt-5a isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK036824, CT025649
      Consensus CDS
      CCDS56946.1
      UniProtKB/Swiss-Prot
      P22725
      Related
      ENSMUSP00000107891.2, ENSMUST00000112272.2
      Conserved Domains (1) summary
      cd19347
      Location:49360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    2. NM_009524.4NP_033550.2  protein Wnt-5a isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK031512, AK031597, AK036824, BY721304, CT025649
      Consensus CDS
      CCDS26888.1
      UniProtKB/Swiss-Prot
      P22725, Q8BM17, Q8BMF9, Q8VCV6
      Related
      ENSMUSP00000064878.5, ENSMUST00000063465.12
      Conserved Domains (1) summary
      cd19347
      Location:69380
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      28224962..28249405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247779.2XP_030103639.1  protein Wnt-5a isoform X2

      Conserved Domains (1) summary
      cd19347
      Location:49360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    2. XM_006518924.4XP_006518987.1  protein Wnt-5a isoform X2

      UniProtKB/Swiss-Prot
      P22725
      Conserved Domains (1) summary
      cd19347
      Location:49360
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
    3. XM_006518923.4XP_006518986.1  protein Wnt-5a isoform X1

      Conserved Domains (1) summary
      cd19347
      Location:82393
      Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
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