Ly6d lymphocyte antigen 6 family member D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ly6dprovided by MGI
Official Full Name: lymphocyte antigen 6 family member Dprovided by MGI
Primary source: MGI:MGI:96881
See related: Ensembl:ENSMUSG00000034634 AllianceGenome:MGI:96881
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Thb; Ly61; Ly-61
Summary: Involved in lymphocyte differentiation and response to stilbenoid. Located in cell surface. Is expressed in adrenal gland; alimentary system; naris; ureter; and vibrissa. Orthologous to human LY6D (lymphocyte antigen 6 family member D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 542.7), spleen adult (RPKM 533.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74633905..74635416, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74762056..74763567, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells.
Title: Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells.
LY6D as a Chemoresistance Marker Gene and Therapeutic Target for Laryngeal Squamous Cell Carcinoma.
Title: LY6D as a Chemoresistance Marker Gene and Therapeutic Target for Laryngeal Squamous Cell Carcinoma.
Expression of RAG-1 and display of Ly6D are both milestone events, but they are neither synchronized nor dependent on each other.
Title: RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage.
identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor
Title: Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Data show that ten genes (Fsp27, Aqp4, Cd36, Ly6d, Scd1, Hsd3b5, Syt1, Cyp7b1, and Tff3) showed significant associations among their expressions and the degree of hepatic steatosis.
Title: Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in lymphocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lymphocyte antigen 6D

Names: ly-6D; lymphocyte antigen 6 complex, locus D; thymocyte B-cell antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.