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    Nat8 N-acetyltransferase 8 (GCN5-related) [ Mus musculus (house mouse) ]

    Gene ID: 68396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nat8provided by MGI
    Official Full Name
    N-acetyltransferase 8 (GCN5-related)provided by MGI
    Primary source
    MGI:MGI:1915646
    See related
    Ensembl:ENSMUSG00000030004 AllianceGenome:MGI:1915646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cml4; CCNAT; ATase2; 0610037O16Rik
    Summary
    Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in gastrulation with mouth forming second. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 43.2), duodenum adult (RPKM 18.8) and 4 other tissues See more
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    Genomic context

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    See Nat8 in Genome Data Viewer
    Location:
    6 C3; 6 37.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85807369..85813839, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85830387..85836857, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 6 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 5 Neighboring gene prostaglandin E synthase 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_16509 Neighboring gene predicted gene, 38847

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Rigby MJ, et al. Commun Biol, 2021 Apr 12. PMID 33846551, Free PMC Article
    2. The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats. Fu J, et al. PLoS One, 2014. PMID 25057902, Free PMC Article
    3. DUX is a non-essential synchronizer of zygotic genome activation. De Iaco A, et al. Development, 2020 Jan 23. PMID 31806660, Free PMC Article
    4. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. Popsueva AE, et al. Dev Biol, 2001 Jun 15. PMID 11397015
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that Nat8 is down-regulated in liver ischemia/reperfusion injury and its upregulation prevents it suggesting its protective effect against liver injuries.
      Title: The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-S-conjugate N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-S-conjugate N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell adhesion ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in peptidyl-lysine N6-acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT located_in late recombination nodule ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetyltransferase 8
    Names
    N-acetyltransferase 8 (GCN5-related, putative)
    acetyltransferase 2
    camello-like 4
    camello-like protein 4
    cysteinyl-conjugate N-acetyltransferase
    probable N-acetyltransferase CML4
    NP_001348989.1
    NP_075944.1
    XP_006506599.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362060.1 → NP_001348989.1  N-acetyltransferase 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161888
      Consensus CDS
      CCDS20301.1
      UniProtKB/Swiss-Prot
      Q9JIY7
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_023455.4 → NP_075944.1  N-acetyltransferase 8

      See identical proteins and their annotated locations for NP_075944.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC161888
      Consensus CDS
      CCDS20301.1
      UniProtKB/Swiss-Prot
      Q9JIY7
      Related
      ENSMUSP00000032073.7, ENSMUST00000032073.7
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85807369..85813839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506536.3 → XP_006506599.1  N-acetyltransferase 8 isoform X1

      See identical proteins and their annotated locations for XP_006506599.1

      UniProtKB/Swiss-Prot
      Q9JIY7
      Conserved Domains (1) summary
      pfam00583
      Location:91 → 193
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIY7.1 GenPept UniProtKB/Swiss-Prot:Q9JIY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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