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    Metap1d methionyl aminopeptidase type 1D (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 66559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Metap1dprovided by MGI
    Official Full Name
    methionyl aminopeptidase type 1D (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1913809
    See related
    Ensembl:ENSMUSG00000041921 AllianceGenome:MGI:1913809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Map1d; MAP 1D; Metapl1; MetAP 1D; 2310066F24Rik; 3110033D18Rik
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 8.6), CNS E14 (RPKM 7.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Metap1d in Genome Data Viewer
    Location:
    2 C2; 2 42.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (71283625..71355538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (71453281..71525194)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Aralar), member 12 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71198352-71198535 Neighboring gene STARR-seq mESC enhancer starr_04786 Neighboring gene STARR-seq mESC enhancer starr_04790 Neighboring gene VISTA enhancer mm55 Neighboring gene histone aminotransferase 1 Neighboring gene nuclear protein-NHP2-like protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_04791 Neighboring gene STARR-seq mESC enhancer starr_04792 Neighboring gene distal-less homeobox 1, antisense Neighboring gene distal-less homeobox 1 Neighboring gene distal-less homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrating genetic and network analysis to characterize genes related to mouse weight. Ghazalpour A, et al. PLoS Genet, 2006 Aug 18. PMID 16934000, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase 1D, mitochondrial
    Names
    metAP 1D
    methionine aminopeptidase-like 1
    peptidase M 1D
    NP_001405450.1
    NP_001405451.1
    NP_001405452.1
    NP_001405453.1
    NP_001405454.1
    NP_001405455.1
    NP_079909.1
    XP_006500072.1
    XP_011238040.1
    XP_017174676.1
    XP_017174677.1
    XP_017174678.1
    XP_017174679.1
    XP_017174680.1
    XP_030107808.1
    XP_030107809.1
    XP_030107812.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418521.1 → NP_001405450.1  methionine aminopeptidase 1D, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931

    2. NM_001418522.1 → NP_001405451.1  methionine aminopeptidase 1D, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931

    3. NM_001418523.1 → NP_001405452.1  methionine aminopeptidase 1D, mitochondrial isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931

    4. NM_001418524.1 → NP_001405453.1  methionine aminopeptidase 1D, mitochondrial isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931
      UniProtKB/TrEMBL
      Q9CRV0

    5. NM_001418525.1 → NP_001405454.1  methionine aminopeptidase 1D, mitochondrial isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931
      UniProtKB/TrEMBL
      Q9CRV0

    6. NM_001418526.1 → NP_001405455.1  methionine aminopeptidase 1D, mitochondrial isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AL928931
      UniProtKB/TrEMBL
      Q9CRV0

    7. NM_025633.4 → NP_079909.1  methionine aminopeptidase 1D, mitochondrial isoform 3 precursor

      See identical proteins and their annotated locations for NP_079909.1

      Status: VALIDATED

      Source sequence(s)
      AL928931
      Consensus CDS
      CCDS16115.1
      UniProtKB/Swiss-Prot
      Q80WB3, Q91YD2, Q9CPW9
      Related
      ENSMUSP00000048190.9, ENSMUST00000037210.9
      Conserved Domains (1) summary
      cd01086
      Location:94 → 330
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    RNA

    1. NR_184762.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    2. NR_184763.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    3. NR_184764.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    4. NR_184765.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    5. NR_184766.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    6. NR_184767.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    7. NR_184768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    8. NR_184769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    9. NR_184770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    10. NR_184771.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    11. NR_184772.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    12. NR_184773.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    13. NR_184774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928931

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      71283625..71355538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319187.2 → XP_017174676.1  methionine aminopeptidase 1D, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00279
      Location:94 → 336
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    2. XM_017319188.1 → XP_017174677.1  methionine aminopeptidase 1D, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00279
      Location:94 → 234
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    3. XM_017319190.3 → XP_017174679.1  methionine aminopeptidase 1D, mitochondrial isoform X5

      Conserved Domains (1) summary
      cl00279
      Location:94 → 239
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    4. XM_017319189.3 → XP_017174678.1  methionine aminopeptidase 1D, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl00279
      Location:94 → 234
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    5. XM_017319191.1 → XP_017174680.1  methionine aminopeptidase 1D, mitochondrial isoform X6

      Conserved Domains (1) summary
      cl00279
      Location:94 → 237
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    6. XM_030251949.1 → XP_030107809.1  methionine aminopeptidase 1D, mitochondrial isoform X8

      Conserved Domains (1) summary
      cd01086
      Location:1 → 280
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    7. XM_006500009.4 → XP_006500072.1  methionine aminopeptidase 1D, mitochondrial isoform X8

      See identical proteins and their annotated locations for XP_006500072.1

      Related
      ENSMUST00000139045.8
      Conserved Domains (1) summary
      cd01086
      Location:1 → 280
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    8. XM_030251948.1 → XP_030107808.1  methionine aminopeptidase 1D, mitochondrial isoform X8

      Conserved Domains (1) summary
      cd01086
      Location:1 → 280
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    9. XM_030251952.2 → XP_030107812.1  methionine aminopeptidase 1D, mitochondrial isoform X9

      Conserved Domains (1) summary
      cd01086
      Location:1 → 212
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    10. XM_011239738.4 → XP_011238040.1  methionine aminopeptidase 1D, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd01086
      Location:111 → 415
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    RNA

    1. XR_001783162.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPW9.1 GenPept UniProtKB/Swiss-Prot:Q9CPW9

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