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    Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 54200, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sult2b1provided by MGI
    Official Full Name
    sulfotransferase family, cytosolic, 2B, member 1provided by MGI
    Primary source
    MGI:MGI:1926342
    See related
    Ensembl:ENSMUSG00000003271 AllianceGenome:MGI:1926342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ST2B1; SULT2B
    Summary
    Enables sulfotransferase activity. Acts upstream of or within sulfate assimilation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14. Orthologous to human SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 60.2), large intestine adult (RPKM 56.9) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sult2b1 in Genome Data Viewer
    Location:
    7 B3; 7 29.47 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45379405..45409096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45729981..45759672, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52973256-52973443 Neighboring gene sphingosine kinase 2 Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52988906-52989102 Neighboring gene STARR-seq mESC enhancer starr_18855 Neighboring gene predicted gene, 31597 Neighboring gene predicted gene, 39009 Neighboring gene predicted gene 5897 Neighboring gene lemur tyrosine kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sulfate assimilation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sulfotransferase 2B1
    Names
    alcohol sulfotransferase
    hydroxysteroid sulfotransferase 2
    sulfotransferase 2B
    NP_001347713.1
    NP_059493.2
    XP_006541061.1
    XP_006541062.1
    XP_030098652.1
    XP_030098653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360784.1NP_001347713.1  sulfotransferase 2B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167242, BM899747
      Consensus CDS
      CCDS90241.1
      UniProtKB/TrEMBL
      A0A1B0GR49, A0A1B0GST5
      Related
      ENSMUSP00000148064.2, ENSMUST00000210754.2
      Conserved Domains (1) summary
      pfam00685
      Location:91334
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_017465.3NP_059493.2  sulfotransferase 2B1 isoform 1

      See identical proteins and their annotated locations for NP_059493.2

      Status: VALIDATED

      Source sequence(s)
      AC167242, AI851328, BM899747, CJ043038, CJ048619, CJ054084
      Consensus CDS
      CCDS21263.1
      UniProtKB/Swiss-Prot
      O35400, Q8K472, Q91V03
      UniProtKB/TrEMBL
      A0A1B0GR49
      Related
      ENSMUSP00000075005.8, ENSMUST00000075571.16
      Conserved Domains (1) summary
      pfam00685
      Location:57300
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45379405..45409096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242793.1XP_030098653.1  sulfotransferase 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GR49
      Conserved Domains (1) summary
      pfam00685
      Location:18261
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_030242792.1XP_030098652.1  sulfotransferase 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GR49
      Conserved Domains (1) summary
      pfam00685
      Location:18261
      Sulfotransfer_1; Sulfotransferase domain
    3. XM_006540999.2XP_006541062.1  sulfotransferase 2B1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GR49
      Related
      ENSMUSP00000147374.2, ENSMUST00000209739.2
      Conserved Domains (1) summary
      pfam00685
      Location:18261
      Sulfotransfer_1; Sulfotransferase domain
    4. XM_006540998.3XP_006541061.1  sulfotransferase 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GR49
      Conserved Domains (1) summary
      pfam00685
      Location:53296
      Sulfotransfer_1; Sulfotransferase domain