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    Neurl1a neuralized E3 ubiquitin protein ligase 1A [ Mus musculus (house mouse) ]

    Gene ID: 18011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neurl1aprovided by MGI
    Official Full Name
    neuralized E3 ubiquitin protein ligase 1Aprovided by MGI
    Primary source
    MGI:MGI:1334263
    See related
    Ensembl:ENSMUSG00000006435 AllianceGenome:MGI:1334263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nlz; Neu1; Neur1; Neurl; Rnf67; Neurl1; 2410129E16Rik
    Summary
    Enables translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of filopodium assembly; positive regulation of long-term neuronal synaptic plasticity; and regulation of synapse organization. Acts upstream of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and plasma membrane. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 25.9), cortex adult (RPKM 23.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Neurl1a in Genome Data Viewer
    Location:
    19 C3; 19 39.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47167259..47247880)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47178820..47259441)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11679 Neighboring gene calcium homeostasis modulator 3 Neighboring gene H1.11 linker histone, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46341 Neighboring gene predicted gene, 36693 Neighboring gene SH3 and PX domains 2A Neighboring gene STARR-seq mESC enhancer starr_46347 Neighboring gene microRNA 6995 Neighboring gene predicted gene, 29834

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation factor activity, non-nucleic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of epidermal growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of long-term neuronal synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEURL1
    Names
    RING-type E3 ubiquitin transferase NEURL1
    m-neu1
    m-neuralized 1
    neuralized homolog 1A
    neuralized-like homolog
    neuralized-like protein 1
    neuralized-like protein 1A
    neuralized1
    NP_001156952.1
    NP_067335.4
    XP_036017349.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163480.1NP_001156952.1  E3 ubiquitin-protein ligase NEURL1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132288, BC058386, BC099702
      Consensus CDS
      CCDS50463.1
      UniProtKB/TrEMBL
      Q499W5
      Related
      ENSMUSP00000107438.4, ENSMUST00000111807.5
      Conserved Domains (4) summary
      smart00588
      Location:44166
      NEUZ; domain in neuralized proteins
      pfam07177
      Location:48113
      Neuralized; Neuralized
      pfam13920
      Location:501550
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:278429
      SPRY; SPRY domain
    2. NM_021360.4NP_067335.4  E3 ubiquitin-protein ligase NEURL1 isoform 1

      See identical proteins and their annotated locations for NP_067335.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC058386, BC099702
      Consensus CDS
      CCDS29890.1
      UniProtKB/Swiss-Prot
      Q91ZT6, Q923S6, Q9CWF1, Q9QWF1
      UniProtKB/TrEMBL
      Q499W5
      Related
      ENSMUSP00000107439.4, ENSMUST00000111808.11
      Conserved Domains (4) summary
      smart00588
      Location:61183
      NEUZ; domain in neuralized proteins
      pfam07177
      Location:65130
      Neuralized; Neuralized
      pfam13920
      Location:518567
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:295446
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47167259..47247880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161456.1XP_036017349.1  E3 ubiquitin-protein ligase NEURL1 isoform X1

      UniProtKB/TrEMBL
      Q499W5
      Conserved Domains (3) summary
      smart00588
      Location:45167
      NEUZ; domain in neuralized proteins
      cd16785
      Location:503546
      mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins
      pfam07177
      Location:280431
      Neuralized