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    Taldo1 transaldolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 21351, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taldo1provided by MGI
    Official Full Name
    transaldolase 1provided by MGI
    Primary source
    MGI:MGI:1274789
    See related
    Ensembl:ENSMUSG00000025503 AllianceGenome:MGI:1274789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a key enzyme of the nonoxidative pentose phosphate pathway that provides ribose-5-phosphate for nucleic acid synthesis and nicotinamide adenine dinucleotide phosphate (NADPH) for lipid biosynthesis. The encoded protein is important for maintaining structure and function of mitochondria. Studies in knockout mice identify that deficiency of this gene product is a cause of sperm dysmotility and male infertility. Deficiency of this protein has also been identified as a cause of hepatocarcinogenesis in mice. Two related pseudogenes have been identified on chromosome 10. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 211.6), subcutaneous fat pad adult (RPKM 187.0) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taldo1 in Genome Data Viewer
    Location:
    7 F5; 7 86.73 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140972073..140982889)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141392160..141402976)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene EPS8-like 2 Neighboring gene RIKEN cDNA B230206H07 gene Neighboring gene STARR-seq mESC enhancer starr_20489 Neighboring gene predicted gene, 25725 Neighboring gene STARR-positive B cell enhancer ABC_E8223 Neighboring gene STARR-positive B cell enhancer ABC_E3761 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene glutamine amidotransferase like class 1 domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transaldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transaldolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transaldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transaldolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glyceraldehyde-3-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pentose-phosphate shunt, non-oxidative branch ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011528.4NP_035658.1  transaldolase

      See identical proteins and their annotated locations for NP_035658.1

      Status: REVIEWED

      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS22011.1
      UniProtKB/Swiss-Prot
      P70358, P70703, Q52KM4, Q93092
      UniProtKB/TrEMBL
      A0A1B0GR11
      Related
      ENSMUSP00000026576.5, ENSMUST00000026576.5
      Conserved Domains (2) summary
      PRK05269
      Location:11329
      PRK05269; transaldolase B; Provisional
      PTZ00411
      Location:11330
      PTZ00411; transaldolase-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140972073..140982889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)