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    Etv5 ets variant 5 [ Mus musculus (house mouse) ]

    Gene ID: 104156, updated on 9-Dec-2024

    Summary

    Official Symbol
    Etv5provided by MGI
    Official Full Name
    ets variant 5provided by MGI
    Primary source
    MGI:MGI:1096867
    See related
    Ensembl:ENSMUSG00000013089 AllianceGenome:MGI:1096867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERM; 1110005E01Rik; 8430401F14Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuromuscular synaptic transmission; regulation of branching involved in mammary gland duct morphogenesis; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study T-cell adult acute lymphocytic leukemia. Orthologous to human ETV5 (ETS variant transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 31.7), lung adult (RPKM 30.1) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Etv5 in Genome Data Viewer
    Location:
    16 B1; 16 13.3 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22200063..22258320, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22381313..22439570, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40389 Neighboring gene STARR-seq mESC enhancer starr_40390 Neighboring gene transformer 2 beta Neighboring gene STARR-seq mESC enhancer starr_40391 Neighboring gene STARR-seq mESC enhancer starr_40392 Neighboring gene STARR-seq mESC enhancer starr_40393 Neighboring gene G protein subunit gamma 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40394 Neighboring gene STARR-seq mESC enhancer starr_40398 Neighboring gene STARR-seq mESC enhancer starr_40399 Neighboring gene STARR-seq mESC enhancer starr_40400 Neighboring gene STARR-seq mESC enhancer starr_40406 Neighboring gene STARR-positive B cell enhancer ABC_E394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:22498212-22498365 Neighboring gene RIKEN cDNA 9230117E06 gene Neighboring gene diacylglycerol kinase, gamma Neighboring gene mitochondrial import inner membrane translocase subunit Tim21 pseudogene Neighboring gene microRNA 8095

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male germ-line stem cell asymmetric division ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ETS translocation variant 5
    Names
    ets variant gene 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358428.1NP_001345357.1  ETS translocation variant 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154605, CT009627
      Consensus CDS
      CCDS37299.1
      UniProtKB/Swiss-Prot
      Q3TG49, Q8C0F3, Q9CXC9, Q9JHB1
      UniProtKB/TrEMBL
      Q8BJR1
      Conserved Domains (2) summary
      smart00413
      Location:367452
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2366
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    2. NM_023794.2NP_076283.2  ETS translocation variant 5

      See identical proteins and their annotated locations for NP_076283.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC034680
      Consensus CDS
      CCDS37299.1
      UniProtKB/Swiss-Prot
      Q3TG49, Q8C0F3, Q9CXC9, Q9JHB1
      UniProtKB/TrEMBL
      Q8BJR1
      Related
      ENSMUSP00000078551.7, ENSMUST00000079601.13
      Conserved Domains (2) summary
      smart00413
      Location:367452
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:2366
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22200063..22258320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)