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    C1qtnf6 C1q and tumor necrosis factor related protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 72709, updated on 9-Dec-2024

    Summary

    Official Symbol
    C1qtnf6provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 6provided by MGI
    Primary source
    MGI:MGI:1919959
    See related
    Ensembl:ENSMUSG00000022440 AllianceGenome:MGI:1919959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adiq; CTRP6; 2810036M19Rik
    Summary
    Enables identical protein binding activity. Located in extracellular space. Part of protein-containing complex. Orthologous to human C1QTNF6 (C1q and TNF related 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 62.8), limb E14.5 (RPKM 28.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See C1qtnf6 in Genome Data Viewer
    Location:
    15 E1; 15 37.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78407546..78416370, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78523346..78532170, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 6 Neighboring gene STARR-positive B cell enhancer ABC_E8598 Neighboring gene STARR-seq mESC enhancer starr_39146 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:78306098-78306207 Neighboring gene interleukin 2 receptor, beta chain Neighboring gene STARR-positive B cell enhancer ABC_E4139 Neighboring gene STARR-seq mESC enhancer starr_39149 Neighboring gene somatostatin receptor 3 Neighboring gene L antigen family, member 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    complement C1q tumor necrosis factor-related protein 6
    Names
    adiponectin q

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204152.1NP_001191081.1  complement C1q tumor necrosis factor-related protein 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001191081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI853798, AK012868, AL590144
      Consensus CDS
      CCDS88801.1
      UniProtKB/TrEMBL
      A0A2R8W6P9
      Related
      ENSMUSP00000155221.2, ENSMUST00000229185.2
    2. NM_001204153.1NP_001191082.1  complement C1q tumor necrosis factor-related protein 6 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001191082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL590144
      Related
      ENSMUST00000147093.2
    3. NM_028331.5NP_082607.3  complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082607.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI853798, AK012868, AL590144, DQ002399
      Consensus CDS
      CCDS37134.1
      UniProtKB/Swiss-Prot
      Q6IR41, Q8BKR0
      UniProtKB/TrEMBL
      A0A3B0IP29
      Related
      ENSMUSP00000023075.9, ENSMUST00000023075.9
      Conserved Domains (2) summary
      pfam01391
      Location:83122
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:131259
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78407546..78416370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521455.4XP_006521518.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006521518.1

      Conserved Domains (2) summary
      pfam01391
      Location:79118
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:127255
      C1q; C1q domain
    2. XM_006521452.5XP_006521515.1  complement C1q tumor necrosis factor-related protein 6 isoform X2

      Conserved Domains (2) summary
      pfam01391
      Location:111150
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:159287
      C1q; C1q domain
    3. XM_036159608.1XP_036015501.1  complement C1q tumor necrosis factor-related protein 6 isoform X1

      Conserved Domains (2) summary
      pfam00386
      Location:175303
      C1q; C1q domain
      pfam01391
      Location:127166
      Collagen; Collagen triple helix repeat (20 copies)
    4. XM_006521453.4XP_006521516.1  complement C1q tumor necrosis factor-related protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006521516.1

      Conserved Domains (2) summary
      pfam01391
      Location:79118
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:127255
      C1q; C1q domain
    5. XM_036159609.1XP_036015502.1  complement C1q tumor necrosis factor-related protein 6 isoform X4