YND1 apyrase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YND1
Official Full Name: apyrase
Primary source: SGD:S000000807
Locus tag: YER005W
See related: AllianceGenome:SGD:S000000807; FungiDB:YER005W; VEuPathDB:YER005W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: APY1; YEJ5
Summary: Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Involved in protein glycosylation. Located in Golgi membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YND1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (160550..162442)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies sugget that the Ynd1 cytoplasmic tail acts as a scaffold, interacting with a multi-protein complex, whose targeting by E4orf4 leads to cell death.
Title: The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.
Ynd1p and Cdc55p share a common downstream target whose balanced modulation by the two E4orf4 partners is crucial to viability
Title: YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.
Sequential deletion analysis reveals that translocation of this 500-residue-long hydrophilic domain across the membranes requires the C-terminal transmembrane domain of Ynd1p and its flanking regions.
Title: A eukaryotic carboxyl-terminal signal sequence translocating large hydrophilic domains across membranes.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables apyrase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in CTP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: apyrase

NP_010920.3

EC 3.6.1.5

Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

160550..162442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178896.3 → NP_010920.3 TPA: apyrase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010920.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLQ1, P40009, Q6B252

UniProtKB/TrEMBL

B3LS16, B5VHD6, C8Z703, N1P7G6

Conserved Domains (1) summary

COG5371
Location:6 → 619

COG5371; Golgi nucleoside diphosphatase [Nucleotide transport and metabolism]