Il17d interleukin 17D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il17dprovided by MGI
Official Full Name: interleukin 17Dprovided by MGI
Primary source: MGI:MGI:2446510
See related: Ensembl:ENSMUSG00000050222 AllianceGenome:MGI:2446510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IL-17D
Summary: Predicted to enable cytokine activity and protein homodimerization activity. Predicted to be involved in inflammatory response; negative regulation of hemopoiesis; and positive regulation of cytokine production. Predicted to be located in extracellular space. Is expressed in central nervous system; ganglia; nucleus pulposus; and thymus primordium. Orthologous to human IL17D (interleukin 17D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 30.3), colon adult (RPKM 25.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 30.1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (57762197..57780623)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (57524829..57543166)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice deficient in IL-17D or the transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of IL-17D, featured an early decreased number of innate immune cells at the point of viral entry and were more susceptible to mouse cytomegalovirus infection.
Title: Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.
a new role for nuclear factor erythroid-derived 2-like 2 (Nrf2) in regulating early anti-cancer immune responses by inducing IL-17D and recruiting natural killer (NK) cells.
Title: The ancient cytokine IL-17D is regulated by Nrf2 and mediates tumor and virus surveillance.
Nrf2 Induces IL-17D to mediate tumor and virus surveillance.
Title: Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

RH136357 (e-PCR)
- UniSTS:210347

AI462269 (e-PCR)
- UniSTS:180669

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-17D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.