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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001037741.4 → NP_001032830.2 phospholipid hydroperoxide glutathione peroxidase GPX4 isoform B
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. The resulting isoform (B) has a longer and a distinct N-terminus compared to isoform A. A similar isoform in rat (snGPx) has been reported to be localized in the sperm nucleus (PMID:11344099).
- Source sequence(s)
-
AC159999, AK006441, CX733872
- Consensus CDS
-
CCDS24007.1
- UniProtKB/TrEMBL
-
Q76LV0
- Related
- ENSMUSP00000094863.5, ENSMUST00000097227.11
- Conserved Domains (1) summary
-
- cd00340
Location:96 → 249
- GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
-
NM_001367995.1 → NP_001354924.1 phospholipid hydroperoxide glutathione peroxidase GPX4 isoform C
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate promoter, which results in translation initiation from an in-frame downstream AUG start codon compared to variant 1. The encoded isoform (C) has a shorter N-terminus compared to isoform A. A similar isoform in rat (S-form) has been reported to be localized to the cytoplasm (PMID:9988735).
- Source sequence(s)
-
AK006441, CX733872
- UniProtKB/TrEMBL
- Q3TI34, Q5XJZ8
- Related
- ENSMUSP00000138186.3, ENSMUST00000183037.3
-
NM_008162.4 → NP_032188.3 phospholipid hydroperoxide glutathione peroxidase GPX4 isoform A precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the predominant transcript and encodes the canonical isoform A (also known as phGPx). A similar isoform in rat(L-form) has been shown to be localized to the mitochondria (PMID:9988735).
- Source sequence(s)
-
AK006441, BY238083, CX733872
- Consensus CDS
-
CCDS35973.1
- UniProtKB/Swiss-Prot
- O35560, O70325, Q8K4U8, Q91XR9, Q9JK35
- UniProtKB/TrEMBL
-
Q3TIF2
- Related
- ENSMUSP00000101011.3, ENSMUST00000105372.9
- Conserved Domains (1) summary
-
- cd00340
Location:40 → 193
- GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
RNA
-
NR_110342.1 RNA Sequence
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains alternate 5' terminal exons and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
- Source sequence(s)
-
AA510431, AK145770
- Related
-
ENSMUST00000144698.8
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000076.7 Reference GRCm39 C57BL/6J
- Range
-
79883000..79892273
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)