Rcor3 REST corepressor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcor3provided by MGI
Official Full Name: REST corepressor 3provided by MGI
Primary source: MGI:MGI:2441920
See related: Ensembl:ENSMUSG00000037395 AllianceGenome:MGI:2441920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4921514E24Rik; C730034D20Rik; E130101E15Rik
Summary: Enables enzyme binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; limb; and liver. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 10.4), ovary adult (RPKM 4.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.23 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (191782842..191822371, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (192098546..192138074, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In mature erythroid cells, a strong upsurge in Rcor3 and a sharp decline in Rcor1 levels counteract LSD1/Rcor1/2-mediated differentiation.
Title: Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: REST corepressor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290278.2 → NP_001277207.1 REST corepressor 3 isoform b

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Consensus CDS

CCDS69996.1

UniProtKB/Swiss-Prot

Q6PGA0

Related

ENSMUSP00000106473.4, ENSMUST00000110849.10

Conserved Domains (3) summary

smart00717
Location:143 → 189

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001290279.2 → NP_001277208.1 REST corepressor 3 isoform c

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Consensus CDS

CCDS78777.1

UniProtKB/TrEMBL

A0A0A6YWY4

Related

ENSMUSP00000141753.2, ENSMUST00000192491.6

Conserved Domains (2) summary

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001290280.2 → NP_001277209.1 REST corepressor 3 isoform d

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Consensus CDS

CCDS78778.1

UniProtKB/TrEMBL

A0A0A6YWP7

Related

ENSMUSP00000141637.2, ENSMUST00000192128.6

Conserved Domains (4) summary

smart00717
Location:345 → 390

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:345 → 388

Myb_DNA-binding; Myb-like DNA-binding domain

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001290282.2 → NP_001277211.1 REST corepressor 3 isoform e

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

UniProtKB/TrEMBL

B2RSN6

Conserved Domains (2) summary

smart00717
Location:24 → 70

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cl21498
Location:25 → 69

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
NM_001346740.2 → NP_001333669.1 REST corepressor 3 isoform f

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Consensus CDS

CCDS83667.1

UniProtKB/TrEMBL

A0A0A6YXM5

Related

ENSMUSP00000142054.2, ENSMUST00000192866.6
NM_001403274.1 → NP_001390203.1 REST corepressor 3 isoform h

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690
NM_001403275.1 → NP_001390204.1 REST corepressor 3 isoform g

Status: VALIDATED

Source sequence(s)

AC182250, LO018690
NM_144814.4 → NP_659063.3 REST corepressor 3 isoform a

See identical proteins and their annotated locations for NP_659063.3

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Consensus CDS

CCDS69995.1

UniProtKB/Swiss-Prot

Q6PGA0

UniProtKB/TrEMBL

B2RSN6

Related

ENSMUSP00000073004.8, ENSMUST00000073279.13

Conserved Domains (3) summary

smart00717
Location:143 → 189

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam01448
Location:57 → 108

ELM2; ELM2 domain

cl21498
Location:144 → 188

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RNA

NR_175372.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC175315, AC182250, LO018690

Related

ENSMUST00000192158.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

191782842..191822371 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252872.2 → XP_030108732.2 REST corepressor 3 isoform X2

Conserved Domains (2) summary

pfam01448
Location:139 → 190

ELM2; ELM2 domain

cl21498
Location:226 → 270

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_030252875.2 → XP_030108735.2 REST corepressor 3 isoform X3

Conserved Domains (2) summary

pfam01448
Location:139 → 190

ELM2; ELM2 domain

cl21498
Location:226 → 270

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_006497244.4 → XP_006497307.1 REST corepressor 3 isoform X4

See identical proteins and their annotated locations for XP_006497307.1

Conserved Domains (3) summary

pfam00249
Location:226 → 269

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09770
Location:269 → 420

PAT1; Topoisomerase II-associated protein PAT1

cl21498
Location:25 → 69

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_011238931.3 → XP_011237233.1 REST corepressor 3 isoform X4

See identical proteins and their annotated locations for XP_011237233.1

Conserved Domains (3) summary

pfam00249
Location:226 → 269

Myb_DNA-binding; Myb-like DNA-binding domain

pfam09770
Location:269 → 420

PAT1; Topoisomerase II-associated protein PAT1

cl21498
Location:25 → 69

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_030252885.2 → XP_030108745.2 REST corepressor 3 isoform X5

Conserved Domains (2) summary

pfam01448
Location:139 → 190

ELM2; ELM2 domain

cl21498
Location:226 → 270

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...