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    Yju2b YJU2 splicing factor homolog B [ Mus musculus (house mouse) ]

    Gene ID: 67736, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Yju2bprovided by MGI
    Official Full Name
    YJU2 splicing factor homolog Bprovided by MGI
    Primary source
    MGI:MGI:1914986
    See related
    Ensembl:ENSMUSG00000004994 AllianceGenome:MGI:1914986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc130; 4930527D15Rik
    Summary
    Predicted to be involved in RNA splicing. Predicted to be located in nucleus. Predicted to be part of U2-type spliceosomal complex and post-mRNA release spliceosomal complex. Orthologous to human YJU2B (YJU2 splicing factor homolog B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.6), CNS E14 (RPKM 4.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yju2b in Genome Data Viewer
    Location:
    8 C2; 8 40.77 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84984396..84997087, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84257767..84270458, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E59 Neighboring gene zinc finger SWIM-type containing 4 Neighboring gene DNA segment, Chr 8, ERATO Doi 738, expressed Neighboring gene STARR-positive B cell enhancer ABC_E297 Neighboring gene STARR-positive B cell enhancer ABC_E10514 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86815694-86815995 Neighboring gene methylthioribose-1-phosphate isomerase 1 Neighboring gene THO complex 6 homolog pseudogene Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Neighboring gene predicted gene, 23626

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable splicing factor YJU2B
    Names
    coiled-coil domain containing 130
    coiled-coil domain-containing protein 130

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294281.1 → NP_001281210.1  probable splicing factor YJU2B isoform 2

      See identical proteins and their annotated locations for NP_001281210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122794, AK015911, CJ148143
      Consensus CDS
      CCDS80906.1
      UniProtKB/Swiss-Prot
      Q9D516
      Related
      ENSMUSP00000005120.6, ENSMUST00000005120.12
      Conserved Domains (2) summary
      COG5134
      Location:8 → 191
      COG5134; Uncharacterized conserved protein [Function unknown]
      pfam04502
      Location:8 → 198
      DUF572; Family of unknown function (DUF572)

    2. NM_026350.3 → NP_080626.1  probable splicing factor YJU2B isoform 1

      See identical proteins and their annotated locations for NP_080626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122794, AK015911, CJ148143
      Consensus CDS
      CCDS40409.1
      UniProtKB/Swiss-Prot
      Q8VCB4, Q9D516
      UniProtKB/TrEMBL
      Q922B5
      Related
      ENSMUSP00000096177.4, ENSMUST00000098578.10
      Conserved Domains (1) summary
      pfam04502
      Location:9 → 384
      DUF572; Family of unknown function (DUF572)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84984396..84997087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531316.2 → XP_006531379.1  probable splicing factor YJU2B isoform X2

      UniProtKB/TrEMBL
      Q922B5
      Conserved Domains (1) summary
      pfam04502
      Location:1 → 268
      DUF572; Family of unknown function (DUF572)

    2. XM_006531315.5 → XP_006531378.1  probable splicing factor YJU2B isoform X1

      See identical proteins and their annotated locations for XP_006531378.1

      UniProtKB/Swiss-Prot
      Q8VCB4, Q9D516
      UniProtKB/TrEMBL
      Q922B5
      Conserved Domains (1) summary
      pfam04502
      Location:9 → 384
      DUF572; Family of unknown function (DUF572)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D516.1 GenPept UniProtKB/Swiss-Prot:Q9D516

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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