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    Tmem192 transmembrane protein 192 [ Mus musculus (house mouse) ]

    Gene ID: 73067, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem192provided by MGI
    Official Full Name
    transmembrane protein 192provided by MGI
    Primary source
    MGI:MGI:1920317
    See related
    Ensembl:ENSMUSG00000025521 AllianceGenome:MGI:1920317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110005G23Rik
    Summary
    Predicted to enable protein homodimerization activity. Located in lysosome. Orthologous to human TMEM192 (transmembrane protein 192). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 72.3), mammary gland adult (RPKM 26.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem192 in Genome Data Viewer
    Location:
    8 B3.1; 8 32.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65399801..65421688)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64947149..64969036)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45405 Neighboring gene predicted gene, 32507 Neighboring gene tripartite motif-containing 75 Neighboring gene tripartite motif-containing 60 Neighboring gene tripartite motif-containing 61

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the lysosomal membrane protein TMEM192 in mice. Nguyen TL, et al. Oncotarget, 2017 Jul 4. PMID 28504966, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 192

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163747.1 → NP_001157219.1  transmembrane protein 192 isoform 2

      See identical proteins and their annotated locations for NP_001157219.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC099723, AI849438, AK046181
      Consensus CDS
      CCDS52559.1
      UniProtKB/Swiss-Prot
      Q9CXT7
      Related
      ENSMUSP00000078819.8, ENSMUST00000079896.9
      Conserved Domains (1) summary
      pfam14802
      Location:26 → 214
      TMEM192; TMEM192 family

    2. NM_028427.3 → NP_082703.1  transmembrane protein 192 isoform 1

      See identical proteins and their annotated locations for NP_082703.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC099723, AI849438, AK046181
      Consensus CDS
      CCDS22329.1
      UniProtKB/Swiss-Prot
      Q3THT5, Q8VDU8, Q9CXT7
      UniProtKB/TrEMBL
      A0A1B0GS44
      Related
      ENSMUSP00000026595.6, ENSMUST00000026595.13
      Conserved Domains (1) summary
      pfam14802
      Location:26 → 259
      TMEM192; TMEM192 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65399801..65421688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778479.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXT7.1 GenPept UniProtKB/Swiss-Prot:Q9CXT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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