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    Sgtb small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [ Mus musculus (house mouse) ]

    Gene ID: 218544, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sgtbprovided by MGI
    Official Full Name
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, betaprovided by MGI
    Primary source
    MGI:MGI:2444615
    See related
    Ensembl:ENSMUSG00000042743 AllianceGenome:MGI:2444615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630001O05Rik
    Summary
    Predicted to enable Hsp70 protein binding activity; molecular adaptor activity; and protein dimerization activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane; protein heterooligomerization; and protein homooligomerization. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in nervous system and sensory organ. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 25.8), frontal lobe adult (RPKM 19.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgtb in Genome Data Viewer
    Location:
    13 D1; 13 56.23 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104246233..104278369)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104109723..104141861)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene STARR-positive B cell enhancer ABC_E8543 Neighboring gene STARR-seq mESC enhancer starr_35524 Neighboring gene STARR-seq mESC enhancer starr_35525 Neighboring gene STARR-seq mESC enhancer starr_35526 Neighboring gene STARR-seq mESC enhancer starr_35527 Neighboring gene STARR-seq mESC enhancer starr_35528 Neighboring gene STARR-seq mESC enhancer starr_35530 Neighboring gene predicted gene, 30967 Neighboring gene neurolysin (metallopeptidase M3 family) Neighboring gene STARR-positive B cell enhancer mm9_chr13:104881886-104882187 Neighboring gene STARR-positive B cell enhancer ABC_E3099 Neighboring gene trafficking protein particle complex 13 Neighboring gene STARR-positive B cell enhancer ABC_E8896 Neighboring gene STARR-positive B cell enhancer ABC_E385 Neighboring gene STARR-seq mESC enhancer starr_35535 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. Vuong TA, et al. Cell Signal, 2019 Mar. PMID 30639199
    2. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, et al. J Biol Chem, 2003 Oct 3. PMID 12878599
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein beta
    Names
    beta-SGT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361054.1 → NP_001347983.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

      Status: VALIDATED

      Source sequence(s)
      AC154216
      Consensus CDS
      CCDS26746.1
      UniProtKB/Swiss-Prot
      Q8VD33
      Conserved Domains (3) summary
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    2. NM_144838.2 → NP_659087.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

      See identical proteins and their annotated locations for NP_659087.1

      Status: VALIDATED

      Source sequence(s)
      AC154216, BC017611
      Consensus CDS
      CCDS26746.1
      UniProtKB/Swiss-Prot
      Q8VD33
      Related
      ENSMUSP00000041307.8, ENSMUST00000044385.14
      Conserved Domains (3) summary
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerisation domain of SGTA
      cl26005
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104246233..104278369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003950448.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD33.1 GenPept UniProtKB/Swiss-Prot:Q8VD33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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