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    Mss51 MSS51 mitochondrial translational activator [ Mus musculus (house mouse) ]

    Gene ID: 74843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mss51provided by MGI
    Official Full Name
    MSS51 mitochondrial translational activatorprovided by MGI
    Primary source
    MGI:MGI:1922093
    See related
    Ensembl:ENSMUSG00000021815 AllianceGenome:MGI:1922093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zmynd17; 4833444M15Rik
    Summary
    Predicted to enable metal ion binding activity. Orthologous to human MSS51 (MSS51 mitochondrial translational activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 2.9), CNS E11.5 (RPKM 2.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mss51 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20532925..20546969, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20482857..20496901, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 7330404K18 gene Neighboring gene cilia and flagella associated protein 70 Neighboring gene STARR-seq mESC enhancer starr_36110 Neighboring gene annexin A7 Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene ubiquitin specific peptidase 54 Neighboring gene STARR-positive B cell enhancer ABC_E11565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy. Rovira Gonzalez YI, et al. FASEB J, 2021 Feb. PMID 33423297
    2. Distinct Roles of Zmynd17 and PGC1α in Mitochondrial Quality Control and Biogenesis in Skeletal Muscle. Yoshioka K, et al. Front Cell Dev Biol, 2019. PMID 31921843, Free PMC Article
    3. Zmynd17 controls muscle mitochondrial quality and whole-body metabolism. Fujita R, et al. FASEB J, 2018 Sep. PMID 29913553
    4. Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51. Mousa MG, et al. Cell Rep, 2023 Apr 25. PMID 37002920, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Site-1 protease inhibits mitochondrial respiration by controlling the TGF-beta target gene Mss51.
      Title: Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51.
    2. Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy.
      Title: Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy.
    3. indicate that Zmynd17 is a metabolic stress-inducible factor that maintains muscle mitochondrial integrity
      Title: Zmynd17 controls muscle mitochondrial quality and whole-body metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative protein MSS51 homolog, mitochondrial
    Names
    zinc finger MYND domain-containing protein 17
    zinc finger, MYND domain containing 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029104.1 → NP_083380.1  putative protein MSS51 homolog, mitochondrial

      See identical proteins and their annotated locations for NP_083380.1

      Status: VALIDATED

      Source sequence(s)
      AC121801, AK014794, BY341628
      Consensus CDS
      CCDS49414.1
      UniProtKB/Swiss-Prot
      Q0VD61, Q9D5Z5
      Related
      ENSMUSP00000022353.4, ENSMUST00000022353.5
      Conserved Domains (1) summary
      pfam01753
      Location:104 → 148
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20532925..20546969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519636.3 → XP_006519699.1  putative protein MSS51 homolog, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam01753
      Location:12 → 56
      zf-MYND; MYND finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5Z5.1 GenPept UniProtKB/Swiss-Prot:Q9D5Z5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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