Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm6provided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 6provided by MGI
Primary source: MGI:MGI:2447165
See related: Ensembl:ENSMUSG00000032434 AllianceGenome:MGI:2447165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cklfsf6; 2810051A14Rik
Summary: Predicted to be involved in endocytic recycling; protein transport; and regulation of protein stability. Predicted to be located in early endosome membrane; plasma membrane; and recycling endosome membrane. Predicted to be active in membrane. Orthologous to human CMTM6 (CKLF like MARVEL transmembrane domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 31.1), lung adult (RPKM 29.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 65.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (114560184..114578412)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (114731157..114749359)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CMTM6 promotes hepatocellular carcinoma progression through stabilizing beta-catenin.
Title: CMTM6 promotes hepatocellular carcinoma progression through stabilizing β-catenin.
Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye.
Title: Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye.
CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis.
Title: CMTM6 attenuates cisplatin-induced cell death in OSCC by regulating AKT/c-Myc-driven ribosome biogenesis.
CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3beta axis.
Title: CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis.
CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves.
Title: CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 6

Names: chemokine-like factor super family 6; chemokine-like factor superfamily 6; chemokine-like factor superfamily member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.