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    Flt4 FMS-like tyrosine kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 14257, updated on 27-Nov-2024

    Summary

    Official Symbol
    Flt4provided by MGI
    Official Full Name
    FMS-like tyrosine kinase 4provided by MGI
    Primary source
    MGI:MGI:95561
    See related
    Ensembl:ENSMUSG00000020357 AllianceGenome:MGI:95561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chy; Flt-4; VEGFR3; VEGFR-3
    Summary
    Enables vascular endothelial growth factor receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 14.6), ovary adult (RPKM 10.5) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Flt4 in Genome Data Viewer
    Location:
    11 B1.2; 11 29.69 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49500506..49543566)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49609679..49652739)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700024J04 gene Neighboring gene predicted gene, 42075 Neighboring gene predicted gene 12190 Neighboring gene STARR-seq mESC enhancer starr_29379 Neighboring gene secretoglobin, family 3A, member 1 Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene ribosomal protein L30 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vascular endothelial growth factor receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables vascular endothelial growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lymph vessel development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    vascular endothelial growth factor receptor 3
    Names
    chylous ascites
    receptor protein tyrosine kinase
    tyrosine-protein kinase receptor FLT4
    NP_032055.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008029.3NP_032055.1  vascular endothelial growth factor receptor 3 precursor

      See identical proteins and their annotated locations for NP_032055.1

      Status: VALIDATED

      Source sequence(s)
      AL646088, BC138346, BU757635, BY311090
      Consensus CDS
      CCDS24618.1
      UniProtKB/Swiss-Prot
      P35917
      UniProtKB/TrEMBL
      Q5SU94
      Related
      ENSMUSP00000020617.3, ENSMUST00000020617.3
      Conserved Domains (8) summary
      cd05862
      Location:245329
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:570663
      IG; Immunoglobulin
      smart00410
      Location:238327
      IG_like; Immunoglobulin like
      pfam07679
      Location:678765
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:8451169
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:352418
      Ig; Immunoglobulin domain
      cl21453
      Location:8371175
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49500506..49543566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)